An extensive analysis of the prognostic and immune role of FOXO1 in various types of cancer.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-05-03 eCollection Date: 2024-01-01 DOI:10.1590/1414-431X2024e13378

Jie Li, Chao Wang, Xiao Xu, Jun Chen, Haijun Guo

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引用次数: 0

Abstract

Forkhead Box O1 (FOXO1) has been reported to play important roles in many tumors. However, FOXO1 has not been studied in pan-cancer. The purpose of this study was to reveal the roles of FOXO1 in pan-cancer (33 cancers in this study). Through multiple public platforms, a pan-cancer analysis of FOXO1 was conducted to obtained FOXO1 expression profiles in various tumors to explore the relationship between FOXO1 expression and prognosis of these tumors and to disclose the potential mechanism of FOXO1 in these tumors. FOXO1 was associated with the prognosis of multiple tumors, especially LGG (low grade glioma), OV (ovarian carcinoma), and KIRC (kidney renal clear cell carcinoma). FOXO1 might play the role of an oncogenic gene in LGG and OV, while playing the role of a cancer suppressor gene in KIRC. FOXO1 expression had a significant correlation with the infiltration of some immune cells in LGG, OV, and KIRC. By combining FOXO1 expression and immune cell infiltration, we found that FOXO1 might influence the overall survival of LGG through the infiltration of myeloid dendritic cells or CD4+ T cells. Functional enrichment analysis and gene set enrichment analysis showed that FOXO1 might play roles in tumors through immunoregulatory interactions between a lymphoid and a non-lymphoid cell, TGF-beta signaling pathway, and transcriptional misregulation in cancer. FOXO1 was associated with the prognosis of multiple tumors, especially LGG, OV, and KIRC. In these tumors, FOXO1 might play its role via the regulation of the immune microenvironment.

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广泛分析了 FOXO1 在各类癌症中的预后和免疫作用。

据报道，叉头盒 O1（FOXO1）在许多肿瘤中发挥着重要作用。然而，还没有人研究过 FOXO1 在泛癌症中的作用。本研究旨在揭示 FOXO1 在泛癌症（本研究涉及 33 种癌症）中的作用。通过多个公共平台，对 FOXO1 进行泛癌分析，获得 FOXO1 在各种肿瘤中的表达谱，探讨 FOXO1 表达与这些肿瘤预后的关系，并揭示 FOXO1 在这些肿瘤中的潜在机制。FOXO1与多种肿瘤的预后有关，尤其是LGG（低级别胶质瘤）、OV（卵巢癌）和KIRC（肾透明细胞癌）。FOXO1 在 LGG 和 OV 中可能扮演致癌基因的角色，而在 KIRC 中则扮演抑癌基因的角色。FOXO1的表达与LGG、OV和KIRC中一些免疫细胞的浸润有显著相关性。通过将 FOXO1 表达与免疫细胞浸润相结合，我们发现 FOXO1 可能会通过髓系树突状细胞或 CD4+ T 细胞的浸润影响 LGG 的总体存活率。功能富集分析和基因组富集分析表明，FOXO1可能通过淋巴细胞和非淋巴细胞之间的免疫调节相互作用、TGF-beta信号通路以及癌症中的转录失调在肿瘤中发挥作用。FOXO1与多种肿瘤的预后有关，尤其是LGG、OV和KIRC。在这些肿瘤中，FOXO1可能通过调节免疫微环境发挥作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.