Beyond the Maze: Recent Advancements in Molecular and Cellular Tethered Drug Delivery Systems.

IF 1.6 4区医学 Q4 BIOCHEMICAL RESEARCH METHODS

Assay and drug development technologies Pub Date : 2024-05-01 Epub Date: 2024-05-08 DOI:10.1089/adt.2024.025

Dilpreet Singh

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Abstract

The relentless pursuit of precision medicine has catalyzed the development of molecular and cellular tethered drug delivery systems, a burgeoning field that stands to redefine the paradigms of therapeutic delivery. This review encapsulates the cutting-edge advancements within this domain, emphasizing the engineering of molecular tethers and cellular vectors designed to ferry therapeutics directly to their target sites with unparalleled specificity and efficiency. By exploiting the unique biochemical signatures of disease states, these systems promise a substantial reduction in off-target effects and an enhancement in drug bioavailability, thereby mitigating the systemic side effects that are often associated with conventional drug therapies. Through a synthesis of recent research findings, this review highlights the innovative approaches being explored in the design and application of these tethered systems, ranging from nanotechnology-based solutions to genetically engineered cellular carriers. The potential of these systems to provide targeted therapy for a wide array of diseases, including cancer, autoimmune disorders, and neurological conditions, is thoroughly examined. This abstract aims to provide a succinct overview of the current state and future prospects of molecular and cellular tethered drug delivery systems in advancing the frontiers of precision medicine.

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超越迷宫：分子和细胞系留给药系统的最新进展。

对精准医疗的不懈追求催化了分子和细胞系留给药系统的发展，这一新兴领域将重新定义治疗给药模式。这篇综述概括了这一领域的前沿进展，强调了分子系留和细胞载体的工程设计，旨在以无与伦比的特异性和效率将治疗药物直接输送到靶点。通过利用疾病状态的独特生化特征，这些系统有望大大降低脱靶效应，提高药物的生物利用度，从而减轻传统药物疗法经常产生的全身副作用。通过对最新研究成果的综述，本综述重点介绍了在这些系留系统的设计和应用方面正在探索的创新方法，包括基于纳米技术的解决方案和基因工程细胞载体。文章深入探讨了这些系统为癌症、自身免疫性疾病和神经系统疾病等多种疾病提供靶向治疗的潜力。本摘要旨在简明扼要地概述分子和细胞系留给药系统在推动精准医疗前沿发展方面的现状和未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Assay and drug development technologies 医学-生化研究方法

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： ASSAY and Drug Development Technologies provides access to novel techniques and robust tools that enable critical advances in early-stage screening. This research published in the Journal leads to important therapeutics and platforms for drug discovery and development. This reputable peer-reviewed journal features original papers application-oriented technology reviews, topical issues on novel and burgeoning areas of research, and reports in methodology and technology application. ASSAY and Drug Development Technologies coverage includes: -Assay design, target development, and high-throughput technologies- Hit to Lead optimization and medicinal chemistry through preclinical candidate selection- Lab automation, sample management, bioinformatics, data mining, virtual screening, and data analysis- Approaches to assays configured for gene families, inherited, and infectious diseases- Assays and strategies for adapting model organisms to drug discovery- The use of stem cells as models of disease- Translation of phenotypic outputs to target identification- Exploration and mechanistic studies of the technical basis for assay and screening artifacts