BF3·Et2O-assisted synthesis of sulfinylated spiro[5.5]trienones from biaryl ynones†

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-05-29 DOI:10.1039/d3ob02010j

Barnali Roy , Puspendu Kuila , Sangam Jha , Debayan Sarkar

引用次数: 0

Abstract

Sulfinyls are valuable structural moieties used for developing synthetically new pharmaceuticals and agrochemicals. Herein, we disclose a straightforward synthesis of sulfinylated spiro[5.5]trienones proceeding via an unprecedented BF₃·Et₂O-promoted spirocyclization of biaryl ynones. The availability of relatively inexpensive BF₃·Et₂O to carry out transformations on a bulk scale along with its further application towards the synthesis of dibenzocyclohepten-5-ones delivers a unique opportunity to deploy it in various synthetic directions.

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BF3-Et2O 辅助从双芳基炔酮合成亚砜基螺[5.5]三烯酮。

亚磺酰基是用于开发合成新药和农用化学品的重要结构分子。在此，我们公开了一种直接合成亚磺酰基螺[5.5]三烯酮的方法，该方法是通过前所未有的 BF3-Et2O 促进双芳基炔酮的螺环化反应进行的。相对廉价的 BF3-Et2O 可用于进行大规模转化，它还可进一步用于合成二苯并环庚烯-5-酮，这为将其应用于各种合成方向提供了独特的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.