Autism and attention-deficit/hyperactivity disorder in children with Dravet syndrome: A population-based study.

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Developmental Medicine and Child Neurology Pub Date : 2024-11-01 Epub Date: 2024-04-26 DOI:10.1111/dmcn.15937

Colin Reilly, Björn Bjurulf, Tove Hallböök

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引用次数: 0

Abstract

Aim: To identify on a population basis the prevalence of autism and attention-deficit/hyperactivity disorder (ADHD) in children with Dravet syndrome and factors associated with symptoms of autism and ADHD.

Method: Forty-one of 48 children with Dravet syndrome living in Sweden, born between 1st January 2000 and 31st December 2018 underwent assessment including measures of autism and ADHD. Diagnoses of autism and ADHD were made with respect to DSM-5 criteria. Factors associated with features of autism and ADHD were analysed via regression.

Results: Twenty-five of the 41 children fulfilled DSM-5 criteria for autism spectrum disorder and 12 of 37 children considered for an ADHD diagnosis fulfilled DSM-5 criteria for ADHD. Severe intellectual disability was significantly associated with a greater degree of autistic features (p < 0.001) and a DSM-5 diagnosis of autism spectrum disorder (p = 0.029). Younger children had significantly more features of ADHD (p = 0.004) and features of inattention were significantly more common than features of hyperactivity/impulsivity (p < 0.001).

Interpretation: Children with Dravet syndrome often have significant features of autism and ADHD, primarily inattentive type. Screening for autism and ADHD should be routine in children with Dravet syndrome.

What this paper adds: In total, 25 of 41 assessed children with Dravet syndrome fulfilled DSM-5 criteria for autism. Twelve of 37 assessed children with Dravet Syndrome met DSM-5 criteria for attention-deficit/hyperactivity disorder (ADHD). Severe intellectual disability was significantly associated with a greater degree of autism spectrum disorder features. Younger children had significantly more features of ADHD.

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患有德雷维综合征的儿童中的自闭症和注意力缺陷/多动障碍：一项基于人群的研究。

目的：在人群基础上确定自闭症和注意力缺陷/多动障碍（ADHD）在德拉维特综合征患儿中的患病率，以及与自闭症和ADHD症状相关的因素：对居住在瑞典、出生于 2000 年 1 月 1 日至 2018 年 12 月 31 日期间的 48 名德拉维特综合征患儿中的 41 人进行了评估，包括自闭症和多动症的测量。自闭症和多动症的诊断依据DSM-5标准。通过回归分析了与自闭症和多动症特征相关的因素：41 名儿童中有 25 名符合 DSM-5 自闭症谱系障碍标准，37 名被考虑诊断为多动症的儿童中有 12 名符合 DSM-5 多动症标准。严重的智力障碍与自闭症特征的程度明显相关（p 解释：自闭症特征的程度与智力障碍的程度明显相关：德雷维综合征患儿通常具有明显的自闭症和多动症特征，主要是注意力不集中类型。应将自闭症和多动症筛查作为德雷维综合征患儿的常规检查项目。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental Medicine and Child Neurology 医学-临床神经学

CiteScore

7.80

自引率

13.20%

发文量

338

审稿时长

3-6 weeks

期刊介绍： Wiley-Blackwell is pleased to publish Developmental Medicine & Child Neurology (DMCN), a Mac Keith Press publication and official journal of the American Academy for Cerebral Palsy and Developmental Medicine (AACPDM) and the British Paediatric Neurology Association (BPNA). For over 50 years, DMCN has defined the field of paediatric neurology and neurodisability and is one of the world’s leading journals in the whole field of paediatrics. DMCN disseminates a range of information worldwide to improve the lives of disabled children and their families. The high quality of published articles is maintained by expert review, including independent statistical assessment, before acceptance.