Non-coding RNA therapeutics in the treatment of heart failure.

IF 5.3 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

European Heart Journal - Cardiovascular Pharmacotherapy Pub Date : 2024-07-16 DOI:10.1093/ehjcvp/pvae027

Aleksandra Paterek, Marta Załęska-Kocięcka, Mateusz Surzykiewicz, Zuzanna Wojdyńska, Przemysław Leszek, Michał Mączewski

引用次数: 0

Abstract

Non-coding RNA (ncRNA) therapeutics can target either ncRNAs or conventional messenger RNA, offering both superior pharmacokinetics and selectivity to conventional therapies and addressing new, previously unexplored pathways. Although no ncRNA has yet been approved for the treatment of heart failure, in this review we present five most promising pathways and agents that either are in human clinical trials or offer great promise in the near future.

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治疗心力衰竭的非编码 RNA 疗法。

ncRNA 疗法既可以针对 ncRNA，也可以针对传统的 mRNA，与传统疗法相比，具有更优越的药代动力学和选择性，并能解决以前未探索过的新途径。尽管目前还没有 ncRNA 被批准用于治疗心力衰竭，但在本综述中，我们将介绍 5 种最有前景的途径和药物，它们要么正在进行人体临床试验，要么在不久的将来大有可为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Heart Journal - Cardiovascular Pharmacotherapy Medicine-Cardiology and Cardiovascular Medicine

CiteScore

10.10

自引率

14.10%

发文量

期刊介绍： The European Heart Journal - Cardiovascular Pharmacotherapy (EHJ-CVP) is an international, peer-reviewed journal published in English, specifically dedicated to clinical cardiovascular pharmacology. EHJ-CVP publishes original articles focusing on clinical research involving both new and established drugs and methods, along with meta-analyses and topical reviews. The journal's primary aim is to enhance the pharmacological treatment of patients with cardiovascular disease by interpreting and integrating new scientific developments in this field. While the emphasis is on clinical topics, EHJ-CVP also considers basic research articles from fields such as physiology and molecular biology that contribute to the understanding of cardiovascular drug therapy. These may include articles related to new drug development and evaluation, the physiological and pharmacological basis of drug action, metabolism, drug interactions, and side effects.