Immunomodulatory effects of extracellular vesicles from mesenchymal stromal cells: Implication for therapeutic approach in autoimmune diseases.

The Kaohsiung journal of medical sciences Pub Date : 2024-06-01 Epub Date: 2024-05-07 DOI:10.1002/kjm2.12841
Hsiu-Jung Liao, Ping-Ning Hsu
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引用次数: 0

Abstract

Autoimmune disease is characterized by the proliferation of harmful immune cells, inducing tissue inflammation and ultimately causing organ damage. Current treatments often lack specificity, necessitating high doses, prolonged usage, and high recurrence rates. Therefore, the identification of innovative and safe therapeutic strategies is urgently required. Recent preclinical studies and clinical trials on inflammatory and autoimmune diseases have evidenced the immunosuppressive properties of mesenchymal stromal cells (MSCs). Studies have demonstrated that extracellular vesicles (EV) derived from MSCs can mitigate abnormal autoinflammation while maintaining safety within the diseased microenvironment. This study conducted a systematic review to elucidate the crucial role of MSC-EVs in alleviating autoimmune diseases, particularly focusing on their impact on the underlying mechanisms of autoimmune conditions such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and inflammatory bowel disease (IBD). By specifically examining the regulatory functions of microRNAs (miRNAs) derived from MSC-EVs, the comprehensive study aimed to enhance the understanding related to disease mechanisms and identify potential diagnostic markers and therapeutic targets for these diseases.

间充质基质细胞细胞外囊泡的免疫调节作用:对自身免疫性疾病治疗方法的启示
自身免疫性疾病的特点是有害的免疫细胞大量繁殖,诱发组织炎症,最终造成器官损伤。目前的治疗方法往往缺乏特异性,需要大剂量、长时间使用,而且复发率高。因此,迫切需要找到创新、安全的治疗策略。最近关于炎症和自身免疫性疾病的临床前研究和临床试验证明了间充质基质细胞(MSCs)的免疫抑制特性。研究表明,间充质干细胞衍生的细胞外囊泡(EV)可以缓解异常自身炎症,同时保持疾病微环境的安全性。本研究进行了一项系统性综述,以阐明间充质干细胞-细胞外小泡在缓解自身免疫性疾病中的关键作用,尤其是它们对类风湿性关节炎(RA)、系统性红斑狼疮(SLE)和炎症性肠病(IBD)等自身免疫性疾病的潜在机制的影响。这项综合研究旨在通过专门研究来自间充质干细胞-EV的微RNA(miRNA)的调控功能,加深对疾病机制的了解,并确定这些疾病的潜在诊断标志物和治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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