Vascular calcification in Takayasu arteritis: relationship with metabolic syndrome, left ventricular mass index, and intima-media thickness

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Hellenic Journal of Cardiology Pub Date : 2025-09-01 DOI:10.1016/j.hjc.2024.04.007

Hazan Karadeniz , Sevcihan Kesen , Mert Burak Akhan , Serkan Unlu , Rıza Can Kardas , Aslıhan Avanoglu Guler , Derya Yıldırım , Ibrahim Vasi , Burcugul Kaya , Rahime Duran , Nurten Gizem Tore , Abdulsamet Erden , Hamit Kucuk , Berna Goker , Mehmet Akif Ozturk , Abdurrahman Tufan

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引用次数: 0

Abstract

Objective

The present study aims to determine the frequency of vascular calcification in Takayasu arteritis (TA) and the risk factors for it and to evaluate its relation with atherosclerotic predictors such as metabolic syndrome (MS), left ventricular mass index (LVMI) and carotid intima-media thickness (CIMT).

Methods

A cross-sectional study was conducted in patients with TA; MS was defined according to the US National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATP III) criteria. The study included 49 TA patients (22 with MS, 27 without MS) and 31 healthy controls (HCs). Non-contrast computed tomography measured calcification in coronary arteries, aorta, and branches.

Results

Forty-seven patients (95.9%) were female and mean age was 33.45 ± 8.53 years. Total calcification score (mean ± SD; 5223.9 ± 18041.1 AU vs. 35.87 ± 72.70 AU (p = 0.05)), CIMT, and LVMI were found to be significantly higher in TA patients than HCs (p < 0.05). While there was no significant difference between the total calcification score of MS (+) TA patients and MS (−) TA patients, in both patient groups, the total calcification score was found to be significantly higher than HCs. MS (+) and MS (−) groups were found to have significantly higher CIMT and LVMI values than the control group, in addition, MS (+) patients were found to have significantly higher LVMI and CIMT values than MS (−) group (p < 0.05).

Conclusion

Vascular calcification, CIMT, and LVMI are elevated in all TA patients, with greater impact in the presence of MS.

Abstract Image

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高安动脉炎的血管钙化；与代谢综合征、左心室质量指数和内膜厚度的关系

简介：本研究旨在确定高安动脉炎（TA）患者血管钙化的频率及其风险因素，并评估其与代谢综合征（MS）、左心室质量指数（LVMI）和颈动脉内膜中层厚度（CIMT）等动脉粥样硬化预测指标的关系：方法：对TA患者进行了一项横断面研究；MS是根据美国国家胆固醇教育计划/成人治疗小组III（NCEP/ATP III）标准定义的。研究对象包括 49 名 TA 患者（22 名 MS 患者，27 名非 MS 患者）和 31 名健康对照组（HCs）。非对比计算机断层扫描测量了冠状动脉、主动脉和分支的钙化情况：47名患者（95.9%）为女性，平均年龄（33.45±8.53）岁。TA患者的钙化总分（平均值±SD；5223.9±18041.1 AU vs 35.87±72.70 AU（P=0.05））、CIMT和LVMI均显著高于HC（P结论：所有TA患者的血管钙化、CIMT和LVMI均升高，MS患者的影响更大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hellenic Journal of Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

4.90

自引率

7.30%

发文量

审稿时长

56 days

期刊介绍： The Hellenic Journal of Cardiology (International Edition, ISSN 1109-9666) is the official journal of the Hellenic Society of Cardiology and aims to publish high-quality articles on all aspects of cardiovascular medicine. A primary goal is to publish in each issue a number of original articles related to clinical and basic research. Many of these will be accompanied by invited editorial comments. Hot topics, such as molecular cardiology, and innovative cardiac imaging and electrophysiological mapping techniques, will appear frequently in the journal in the form of invited expert articles or special reports. The Editorial Committee also attaches great importance to subjects related to continuing medical education, the implementation of guidelines and cost effectiveness in cardiology.