Lipid-associated macrophages between aggravation and alleviation of metabolic diseases.

IF 11.4 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Trends in Endocrinology and Metabolism Pub Date : 2024-11-01 Epub Date: 2024-05-04 DOI:10.1016/j.tem.2024.04.009
Ruonan Xu, Nemanja Vujić, Valentina Bianco, Isabel Reinisch, Dagmar Kratky, Jelena Krstic, Andreas Prokesch
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引用次数: 0

Abstract

Lipid-associated macrophages (LAMs) are phagocytic cells with lipid-handling capacity identified in various metabolic derangements. During disease development, they locate to atherosclerotic plaques, adipose tissue (AT) of individuals with obesity, liver lesions in steatosis and steatohepatitis, and the intestinal lamina propria. LAMs can also emerge in the metabolically demanding microenvironment of certain tumors. In this review, we discuss major questions regarding LAM recruitment, differentiation, and self-renewal, and, ultimately, their acute and chronic functional impact on the development of metabolic diseases. Further studies need to clarify whether and under which circumstances LAMs drive disease progression or resolution and how their phenotype can be modulated to ameliorate metabolic disorders.

代谢性疾病恶化与缓解之间的脂质相关巨噬细胞。
脂质相关巨噬细胞(LAMs)是一种具有脂质处理能力的吞噬细胞,可在各种代谢失调中被发现。在疾病发展过程中,它们分布在动脉粥样硬化斑块、肥胖症患者的脂肪组织(AT)、脂肪变性和脂肪性肝炎的肝脏病变部位以及肠道固有层。某些肿瘤的代谢微环境中也会出现 LAMs。在这篇综述中,我们将讨论有关 LAM 招募、分化和自我更新的主要问题,以及最终它们对代谢性疾病发展的急性和慢性功能性影响。进一步的研究需要阐明 LAMs 是否以及在何种情况下驱动疾病的发展或缓解,以及如何调节其表型以改善代谢性疾病。
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来源期刊
Trends in Endocrinology and Metabolism
Trends in Endocrinology and Metabolism 医学-内分泌学与代谢
CiteScore
20.10
自引率
0.00%
发文量
98
审稿时长
82 days
期刊介绍: Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage. Explore recent advancements in diabetes, endocrine diseases, obesity, neuroendocrinology, immunometabolism, molecular and cellular biology, and a myriad of other areas through our journal. TEM serves as an invaluable resource for researchers, clinicians, lecturers, teachers, and students. Each monthly issue is anchored by Reviews and Opinion articles, with Reviews meticulously chronicling recent and significant developments, often contributed by leading researchers in specific fields. Opinion articles foster debate and hypotheses. Our shorter pieces include Science & Society, shedding light on issues at the intersection of science, society, and policy; Spotlights, which focus on exciting recent developments in the literature, and single-point hypotheses as Forum articles. We wholeheartedly welcome and encourage responses to previously published TEM content in the form of Letters.
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