The Role of Vitamin D Binding Protein and Vitamin D Level in Mortality of Sepsis Patients.

IF 1.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Reports of Biochemistry and Molecular Biology Pub Date : 2023-10-01 DOI:10.61186/rbmb.12.3.366

Liliriawati Ananta Kahar, Yusrawati Yusrawati, Jamsari Jamsari, Tinni Maskoen, Kornelis Aribowo, Wiwi Monika Sari

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引用次数: 0

Abstract

Background: Vitamin D plays crucial roles in immune cell function, including macrophage activation, immune response modulation, and antimicrobial peptide production. Low vitamin D levels can result in reduced immune response, heightened inflammation, and impaired organ function, thereby exacerbating sepsis severity and impacting patient prognosis. This study investigates the influence of vitamin D binding protein expression and vitamin D levels on the mortality of septic patients.

Methods: This analytical observational study employs a case-control approach and involves patients at the Critical Care Unit of Dr. M. Djamil General Hospital in Padang, Indonesia. The study comprises 40 patients in the case group and 40 patients in the control group. Vitamin D and vitamin D binding protein levels are assessed using the enzyme-linked immunosorbent assay method.

Results: Vitamin D and vitamin D binding protein levels were observed to be lower in the case group compared to the control group. In the case group, the majority of patients had vitamin D binding protein levels below 200 µg/mL. A significant association was found between vitamin D levels and mortality in sepsis patients (P< 0.05). Patients with vitamin D levels below 20 µg/mL faced a 2.54 times higher risk of mortality than those with levels exceeding 20 µg/mL.

Conclusions: Diminished levels of vitamin D binding protein and vitamin D contribute to an increased risk of mortality in septic patients.

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维生素 D 结合蛋白和维生素 D 水平在败血症患者死亡率中的作用

背景：维生素 D 在免疫细胞功能中发挥着至关重要的作用，包括巨噬细胞活化、免疫反应调节和抗菌肽的产生。维生素 D 水平低会导致免疫反应减弱、炎症加剧和器官功能受损，从而加重败血症的严重程度并影响患者的预后。本研究探讨了维生素 D 结合蛋白表达和维生素 D 水平对败血症患者死亡率的影响：这项分析性观察研究采用病例对照方法，涉及印度尼西亚巴东 M. Djamil 医生综合医院重症监护室的患者。研究包括病例组 40 名患者和对照组 40 名患者。采用酶联免疫吸附法评估维生素 D 和维生素 D 结合蛋白水平：结果：与对照组相比，病例组的维生素 D 和维生素 D 结合蛋白水平较低。在病例组中，大多数患者的维生素 D 结合蛋白水平低于 200 微克/毫升。研究发现，脓毒症患者的维生素 D 水平与死亡率之间存在明显联系（P< 0.05）。维生素D水平低于20微克/毫升的患者的死亡风险是维生素D水平超过20微克/毫升的患者的2.54倍：结论：维生素D结合蛋白和维生素D水平的降低会增加脓毒症患者的死亡风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reports of Biochemistry and Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.80

自引率

23.50%

发文量

审稿时长

10 weeks

期刊介绍： The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.