Lower resting state functional connectivity partially mediates adverse effects of prenatal alcohol exposure on arithmetic performance in children

IF 3 Q2 SUBSTANCE ABUSE

Alcohol (Hanover, York County, Pa.) Pub Date : 2024-05-02 DOI:10.1111/acer.15332

Jia Fan, Keri J. Woods, Joseph L. Jacobson, Paul A. Taylor, Jadrana T. F. Toich, Christopher D. Molteno, Sandra W. Jacobson, Ernesta M. Meintjes

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Abstract

Background

Fetal alcohol spectrum disorders (FASD) include a range of neurocognitive and behavioral impairments resulting from prenatal alcohol exposure (PAE). Among the PAE-related cognitive deficits, number processing is particularly affected. This study examines alterations in number processing networks and whether changes in functional connectivity mediate the adverse effects of PAE on arithmetic performance.

Methods

Magnetic resonance imaging (MRI) was acquired in 57 children (mean (SD) age = 11.3 (+0.9) yr), 38 with FASD (19 fetal alcohol syndrome (FAS) or partial FAS (PFAS), 19 heavily exposed (HE)) and 19 controls. Whole-brain correlation analyses were performed from five seeds located in regions involved in number processing.

Results

Children with FAS/PFAS showed dose-dependent reductions in resting state functional connectivity between the seed in the right (R) posterior superior parietal lobule and a cluster in the left (L) inferior frontal gyrus, and between a seed in the R horizontal intraparietal sulcus and clusters in the R precentral gyrus and L cerebellar lobule VI. HE children showed lower resting state functional connectivity in a subset of these regions. Lower functional connectivity in the two fronto-parietal connections partially mediated the adverse effects of PAE on arithmetic performance.

Conclusion

This study demonstrates PAE-related functional connectivity impairments in functional networks involved in number processing. The weaker connectivity between the R posterior superior parietal lobule and the L inferior frontal gyrus suggests that impaired verbal processing and visuospatial working memory may play a role in number processing deficits, while weaker connectivity between the R intraparietal sulcus and the R precentral gyrus points to poorer finger-based numerical representation, which has been linked to arithmetic computational skills.

Abstract Image

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较低的静息状态功能连通性部分介导了产前酒精暴露对儿童算术成绩的不良影响。

背景：胎儿酒精谱系障碍（FASD）包括产前酒精暴露（PAE）导致的一系列神经认知和行为障碍。在与 PAE 相关的认知缺陷中，数字处理尤其受到影响。本研究探讨了数字处理网络的改变，以及功能连接的变化是否介导了 PAE 对算术成绩的不良影响：对 57 名儿童（平均（标清）年龄 = 11.3 (+0.9) 岁）进行了磁共振成像（MRI）检查，其中 38 名儿童患有 FASD（19 名患有胎儿酒精综合征（FAS）或部分 FAS（PFAS），19 名患有严重暴露（HE）），19 名儿童为对照组。对涉及数字处理区域的五颗种子进行了全脑相关性分析：结果：FAS/PFAS 患儿的右侧顶叶后上小叶种子与左侧额叶下回集群之间的静息状态功能连通性，以及右侧顶叶内水平沟种子与右侧中央前回集群和左侧小脑第六小叶之间的静息状态功能连通性，均显示出剂量依赖性降低。HE 儿童在这些区域中的一部分表现出较低的静息状态功能连通性。这两个前顶叶连接区较低的功能连接部分介导了PAE对算术成绩的不良影响：结论：本研究表明，在涉及数字处理的功能网络中，存在与 PAE 相关的功能连接损伤。R后顶叶上小叶和L额叶下回之间较弱的连接性表明，言语处理和视觉空间工作记忆受损可能在数字处理缺陷中起作用，而R顶叶内沟和R中央前回之间较弱的连接性表明，基于手指的数字表征能力较差，这与算术计算技能有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alcohol (Hanover, York County, Pa.)

CiteScore

5.40

自引率

0.00%

发文量