Chemical chaperones in metabolic fitness beyond protein folding.

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Trends in Endocrinology and Metabolism Pub Date : 2024-07-01 Epub Date: 2024-04-24 DOI:10.1016/j.tem.2024.04.006

Ester Zito, Alain Lescure, Nica Borgese

引用次数: 0

Abstract

Chemical chaperones are small molecules that improve protein folding, alleviating aberrant pathological phenotypes due to protein misfolding. Recent reports suggest that, in parallel with their role in relieving endoplasmic reticulum (ER) stress, chemical chaperones rescue mitochondrial function and insulin signaling. These effects may underlie their pharmacological action on metabolically demanding tissues.

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化学伴侣在蛋白质折叠之外的新陈代谢中的作用

化学伴侣是一种能改善蛋白质折叠的小分子，可减轻因蛋白质折叠错误而导致的异常病理表型。最近的报道表明，化学伴侣在缓解内质网（ER）压力的同时，还能挽救线粒体功能和胰岛素信号传导。这些作用可能是化学伴侣对代谢要求高的组织产生药理作用的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

发文量

审稿时长

82 days

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