Sex disparities in the association between serum cotinine and chronic kidney disease.

IF 2.2 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Tobacco Induced Diseases Pub Date : 2024-04-29 eCollection Date: 2024-01-01 DOI:10.18332/tid/185965

Jianling Song, Ping Wang, Hong Li

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引用次数: 0

Abstract

Introduction: Despite the existence of numerous studies highlighting the adverse effects of smoking on kidney function, the investigation of the correlation between serum cotinine and chronic kidney disease (CKD) remains inconclusive due to insufficient evidence. Consequently, the primary objective of this study was to ascertain the association between serum cotinine levels and CKD.

Methods: This study analyzed data from 10900 Americans participating in the National Health and Nutrition Examination Survey between 2005 and 2016. The independent variable under investigation was log serum cotinine, while the dependent variable was the presence of CKD. To investigate the potential linear and non-linear correlations between serum cotinine and CKD, logistic regression models and generalized additive models (GAM) were employed. Furthermore, stratified analyses and interaction tests were conducted to evaluate potential disparities in the relationship between serum cotinine and CKD, based on sex.

Results: The median age in the study participants was 49.28 ± 17.96 years, and the median log serum cotinine (ng/mL) was -0.54 ± 1.68. The prevalence of CKD was found to be 17.04%. Multifactorial regression analysis did not show a statistically significant association between log serum cotinine and CKD (OR=1.02; 95% CI: 0.98-1.06, p=0.4387). A statistically significant non-linear association between log serum cotinine and CKD was also not observed in the GAM analysis (p non-linear value=0.091). Subgroup analyses revealed sex differences in the association between log serum cotinine and CKD. Briefly, males had a positive association between log serum cotinine and incident CKD (OR=1.08; 95% CI: 1.02-1.15, p=0.0049). In females, there was a U-shaped association between log serum cotinine and CKD, with an optimal inflection point for log serum cotinine of -0.30 (serum cotinine=0.5 ng/mL).

Conclusions: Cross-sectional analyses of NHANES data showed gender differences in the association between serum cotinine and the development of CKD.

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血清可替宁与慢性肾病之间的性别差异。

导言：尽管已有大量研究强调了吸烟对肾功能的不利影响，但由于证据不足，对血清中可替宁与慢性肾脏病（CKD）之间相关性的调查仍未得出结论。因此，本研究的主要目的是确定血清中可替宁水平与慢性肾脏病之间的关系：本研究分析了 2005 年至 2016 年间参加全国健康与营养调查的 10900 名美国人的数据。调查的自变量是对数血清可替宁，因变量是是否存在慢性肾脏病。为了研究血清可替宁与慢性肾脏病之间潜在的线性和非线性相关性，研究人员采用了逻辑回归模型和广义加法模型（GAM）。此外，研究人员还进行了分层分析和交互检验，以评估血清可替宁与慢性肾脏病之间的关系在性别上的潜在差异：研究参与者的年龄中位数为（49.28 ± 17.96）岁，血清可替宁对数（纳克/毫升）中位数为（-0.54 ± 1.68）。发现慢性肾脏病的发病率为 17.04%。多因素回归分析表明，血清可替宁对数与慢性肾脏病之间没有统计学意义（OR=1.02；95% CI：0.98-1.06，P=0.4387）。在 GAM 分析中，也没有观察到血清可替宁对数值与慢性肾脏病之间有统计学意义的非线性关联（p 非线性值=0.091）。分组分析显示，血清可替宁对数值与慢性肾脏病之间的关系存在性别差异。简而言之，男性血清可替宁对数值与慢性肾脏病发病率呈正相关（OR=1.08；95% CI：1.02-1.15，p=0.0049）。在女性中，血清可替宁对数与慢性肾脏病之间呈 U 型关联，血清可替宁对数的最佳拐点为-0.30（血清可替宁=0.5 纳克/毫升）：结论：对 NHANES 数据进行的横断面分析表明，血清中的可替宁与慢性肾脏病的发展之间存在性别差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tobacco Induced Diseases SUBSTANCE ABUSE-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

CiteScore

5.30

自引率

5.40%

发文量

审稿时长

12 weeks

期刊介绍： Tobacco Induced Diseases encompasses all aspects of research related to the prevention and control of tobacco use at a global level. Preventing diseases attributable to tobacco is only one aspect of the journal, whose overall scope is to provide a forum for the publication of research articles that can contribute to reducing the burden of tobacco induced diseases globally. To address this epidemic we believe that there must be an avenue for the publication of research/policy activities on tobacco control initiatives that may be very important at a regional and national level. This approach provides a very important "hands on" service to the tobacco control community at a global scale - as common problems have common solutions. Hence, we see ourselves as "connectors" within this global community. The journal hence encourages the submission of articles from all medical, biological and psychosocial disciplines, ranging from medical and dental clinicians, through health professionals to basic biomedical and clinical scientists.