Successful treatment of bifenthrin toxicosis using therapeutic plasma exchange

IF 1.1 3区农林科学 Q3 VETERINARY SCIENCES

Journal of veterinary emergency and critical care Pub Date : 2024-05-06 DOI:10.1111/vec.13377

Alyson H. Fitzgerald DVM, Rebecca K. Davies DVM, DACVECC, Yuntao Zhang PhD, Steve Ensley PhD, DVM, Scott Fritz DVM, DABVT

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引用次数: 0

Abstract

Objective

To describe a case of bifenthrin toxicosis in a dog with a successful outcome following the use of therapeutic plasma exchange (TPE) and intralipid therapy.

Case Summary

An 8-month-old female neutered poodle mix dog ingested an unknown amount of powered bifenthrin, which resulted in acutely altered mentation, cranial nerve deficits, and intractable tremors that persisted in severity despite aggressive medical management to include intravenous fluids, intravenous lipid emulsion, anticonvulsant medications, and methocarbamol. TPE was initiated after lack of significant clinical improvement 12 hours after initial presentation. The dog underwent cardiopulmonary arrest (CPA) following approximately 1 plasma volume equivalent exchange. The dog was successfully resuscitated and showed marked improvement 12 hours postarrest and post-TPE treatment. Serum bifenthrin concentrations were analyzed prior to TPE (445.38 ng/mL) and ∼10 hours after TPE (51.18 ng/mL), which resulted in an 89% reduction in serum bifenthrin concentration.

New Information

TPE may be a promising adjunctive therapeutic modality for bifenthrin toxicosis in dogs.

查看原文本刊更多论文

使用治疗性血浆置换成功治疗联苯菊酯中毒症。

目的：描述一例联苯菊酯中毒病例：描述一例犬联苯菊酯中毒病例，该病例在使用治疗性血浆置换（TPE）和血脂治疗后获得成功。病例摘要：一只 8 个月大的雌性阉割贵宾混血犬摄入了未知剂量的联苯菊酯，导致急性精神改变、颅神经损伤和顽固性震颤，尽管采取了积极的药物治疗，包括静脉输液、静脉注射脂质乳剂、抗惊厥药物和甲氧苄啶，但严重程度依然持续存在。在初次发病 12 小时后，临床症状仍无明显改善，于是开始使用 TPE。在进行了大约 1 次等量血浆置换后，该犬发生了心肺骤停 (CPA)。该犬抢救成功，并在休克后 12 小时和 TPE 治疗后出现明显好转。对 TPE 治疗前（445.38 纳克/毫升）和 TPE 治疗后 10 小时内（51.18 纳克/毫升）的血清联苯菊酯浓度进行了分析，结果显示血清联苯菊酯浓度降低了 89%：新信息：TPE可能是治疗犬联苯菊酯中毒的一种很有前景的辅助治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of veterinary emergency and critical care 农林科学-兽医学

CiteScore

2.50

自引率

15.40%

发文量

121

审稿时长

18-36 weeks

期刊介绍： The Journal of Veterinary Emergency and Critical Care’s primary aim is to advance the international clinical standard of care for emergency/critical care patients of all species. The journal’s content is relevant to specialist and non-specialist veterinarians practicing emergency/critical care medicine. The journal achieves it aims by publishing descriptions of unique presentation or management; retrospective and prospective evaluations of prognosis, novel diagnosis, or therapy; translational basic science studies with clinical relevance; in depth reviews of pertinent topics; topical news and letters; and regular themed issues. The journal is the official publication of the Veterinary Emergency and Critical Care Society, the American College of Veterinary Emergency and Critical Care, the European Veterinary Emergency and Critical Care Society, and the European College of Veterinary Emergency and Critical Care. It is a bimonthly publication with international impact and adheres to currently accepted ethical standards.