Spitz tumour with ALK rearrangement: A case report and literature review.

IF 0.6 4区 医学 Q4 PATHOLOGY
Malaysian Journal of Pathology Pub Date : 2024-04-01
S K Lai, I H Bakrin, N Abd Rauf, S H Abdul Raub
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引用次数: 0

Abstract

Spitz tumour with ALK rearrangement is a recently described entity and a rare tumour. The incidence of Spitz tumour was estimated at 3.63 per 100,000 persons in American paediatric population; while there is no data in Asian population. Here we reported a case of an eleven-year-old Asian boy who presented with a left shin nodule of two months' duration. The skin biopsy revealed a Spitz tumour with predominantly spindle cell morphology arranged in fascicles, vertically orientated nests and radial growth pattern. Junctional component, melanin pigment or Kamino bodies were not identified. Immunohistochemical study displayed homogenous cytoplasmic staining for ALK. Fluorescence in-situ hybridisation (FISH) analysis confirmed ALK rearrangement. Review of the literatures demonstrated that positive ALK immunohistochemistry may not correlate with ALK rearrangement. ALK-rearranged Spitz tumour confirmed with FISH analysis favour clinically benign behaviour despite atypical histomorphology or positive sentinel lymph node. Therefore, correlation of histomorphology, immunohistochemical stain and molecular study are important for the definitive diagnosis of this entity.

Spitz肿瘤伴ALK重排:病例报告和文献综述。
ALK重排的Spitz肿瘤是最近描述的一种罕见肿瘤。据估计,在美国儿科人群中,斯皮茨瘤的发病率为每 10 万人中 3.63 例;而在亚洲人群中则没有相关数据。在此,我们报告了一例 11 岁亚洲男孩的病例,他的左胫骨结节持续了两个月。皮肤活检结果显示,他患的是一种斯皮茨肿瘤,主要呈纺锤形细胞形态,呈束状排列,巢状垂直分布,呈放射状生长。未发现交界成分、黑色素或卡米诺体。免疫组化研究显示,ALK呈均匀的细胞质染色。荧光原位杂交(FISH)分析证实了ALK重排。文献综述表明,ALK免疫组化阳性可能与ALK重排无关。尽管组织形态不典型或前哨淋巴结阳性,但经 FISH 分析证实的 ALK 重排斯皮茨肿瘤临床表现良性。因此,组织形态学、免疫组化染色和分子研究的相关性对于明确诊断这种肿瘤非常重要。
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来源期刊
CiteScore
3.60
自引率
5.60%
发文量
34
期刊介绍: The Malaysian Journal of Pathology is the official journal of the College of Pathologists, Academy of Medicine Malaysia. The primary purpose of The Journal is to publish the results of study and research in Pathology, especially those that have particular relevance to human disease occurring in Malaysia and other countries in this region. The term PATHOLOGY will be interpreted in its broadest sense to include Chemical Pathology, Cytology, Experimental Pathology, Forensic Pathology, Haematology, Histopathology, Immunology, Medical Microbiology and Parasitology. The Journal aims to bring under one cover publications of regional interest embracing the various sub-specialities of Pathology. It is expected that the articles published would be of value not only to pathologists, but also to medical practitioners in search of a scientific basis for the problems encountered in their practice, and to those with an interest in diseases which occur in the tropics.
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