Facilitated lexical processing accuracy and reaction times following repetitive Transcranial Magnetic Stimulation in dementia of the Alzheimer type: a case study.

IF 0.6 4区医学 Q4 CLINICAL NEUROLOGY

Neurocase Pub Date : 2023-10-01 Epub Date: 2024-05-03 DOI:10.1080/13554794.2024.2348222

Georgia Roumpea, Jurij Bon, Katarina Marjanovič, Zvezdan Pirtošek, Christina Manouilidou

引用次数: 0

Abstract

We investigated the potential effects of high-frequency (10 Hz) repetitive Transcranial Magnetic Stimulation (rTMS) of the bilateral Dorsolateral Prefrontal Cortex (DLPFC) (30-sessions; 2-sessions/day) on improving lexical processing in one participant with mild - Alzheimer's disease (hereafter dementia of the Alzheimer type-DAT). Increased accuracy and faster reaction times (RTs) were reported in a lexical-decision task (LDT) up to 2-months post-intervention. The current findings indicate that high-frequency stimulation of the DLPFC might be a potential therapeutic tool to improve lexical processing in mild-DAT.

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重复经颅磁刺激对阿尔茨海默型痴呆症患者词汇处理准确性和反应时间的促进作用：一项病例研究。

我们研究了双侧背外侧前额叶皮层（DLPFC）高频（10赫兹）重复经颅磁刺激（rTMS）（30次/疗程；2次/天）对改善一名轻度阿尔茨海默病（以下简称阿尔茨海默型痴呆-DAT）患者词汇处理能力的潜在影响。据报告，在干预后的两个月内，词汇决策任务（LDT）的准确性和反应时间（RTs）均有所提高。目前的研究结果表明，对DLPFC进行高频刺激可能是一种潜在的治疗工具，可改善轻度阿尔茨海默型痴呆症患者的词汇处理能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurocase 医学-精神病学

CiteScore

1.40

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Neurocase is a rapid response journal of case studies and innovative group studies in neuropsychology, neuropsychiatry and behavioral neurology that speak to the neural basis of cognition. Four types of manuscript are considered for publication: single case investigations that bear directly on issues of relevance to theoretical issues or brain-behavior relationships; group studies of subjects with brain dysfunction that address issues relevant to the understanding of human cognition; reviews of important topics in the domains of neuropsychology, neuropsychiatry and behavioral neurology; and brief reports (up to 2500 words) that replicate previous reports dealing with issues of considerable significance. Of particular interest are investigations that include precise anatomical localization of lesions or neural activity via imaging or other techniques, as well as studies of patients with neurodegenerative diseases, since these diseases are becoming more common as our population ages. Topic reviews are included in most issues.