Panax ginseng Ameliorates Pituitary-Ovarian Dysfunction Induced by Radiofrequency Electromagnetic Radiation from Cell Phones via Upregulation of the CREM Signaling Pathway.

Oyetunji A Oyewopo, Olabimpe C Badejogbin, Isaac O Ajadi, Linus A Enye, Mary B Ajadi, Ikponmwosa V Ebuwa, Olutunmise V Owolabi, Stephanie E Areloegbe, Kehinde S Olaniyi
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Abstract

Background: Panax ginseng (PG) is a plant that contains ginsenosides, which are considered adaptogens that confer cellular protection. However, the impact of PG on pituitary-ovarian dysfunction and subsequent infertility is unknown. This study investigated the hypothesis that PG would attenuate pituitary-ovarian dysfunction associated with mobile phone's Radiofrequency Electromagnetic Radiation (RF-EMR) in experimental rat models and the possible involvement of a cAMP Response Element Modulator (CREM)-dependent pathway.

Methods: Twenty adult female Wistar rats were divided randomly into four groups, each consisting of five rats. The control group was administered a vehicle (distilled water) orally, while the P. ginseng group received 200 mg/kg of P. ginseng extract orally. The RF-EMR group was exposed to 900MHz radiation, and the RF-EMR + PG group was exposed to the same radiation while also being treated with 200 mg/kg of P. ginseng orally. These treatments were administered daily for a period of 56 days.

Results: The RF-EMR group exhibited significant reductions in serum levels of LH, FSH, estradiol, and progesterone compared to the control group. Moreover, levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were significantly lower in the RF-EMR group compared to the control. Additionally, there was a notable decrease in the expression of the CREM gene, accompanied by disrupted pituitary/ovarian morphology in the RF-EMR group compared to the control. However, the administration of PG mitigated these changes.

Conclusion: The findings of this study indicate that P. ginseng extract shields against pituitary-ovarian impairment linked to RF-EMR exposure from cell phones by boosting antioxidant capacity and promoting the CREM-dependent pathway.

三七通过上调CREM信号通路改善手机射频电磁辐射诱发的垂体-卵巢功能障碍
背景:人参(PG)是一种含有人参皂苷的植物,人参皂苷被认为是一种适应原,可为细胞提供保护。然而,人参皂甙对垂体-卵巢功能失调及随后的不孕症的影响尚不清楚。本研究探讨了人参皂苷会减轻实验大鼠模型中与手机射频电磁辐射(RF-EMR)相关的垂体-卵巢功能障碍的假设,以及 cAMP 反应元件调节器(CREM)依赖途径的可能参与:将 20 只成年雌性 Wistar 大鼠随机分为 4 组,每组 5 只。对照组口服载体(蒸馏水),人参组口服 200 毫克/千克人参提取物。射频-电磁辐射组暴露于 900MHz 的辐射中,射频-电磁辐射 + PG 组暴露于相同的辐射中,同时口服 200 毫克/千克的人参。这些治疗每天进行,为期 56 天:结果:与对照组相比,射频-电磁辐射组的血清 LH、FSH、雌二醇和孕酮水平明显下降。此外,与对照组相比,射频-电磁辐射组的超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GPx)水平明显降低。此外,与对照组相比,RF-EMR 组 CREM 基因的表达明显减少,并伴有垂体/卵巢形态的破坏。然而,服用 PG 可减轻这些变化:本研究结果表明,人参提取物可通过提高抗氧化能力和促进 CREM 依赖性途径,防止手机射频-电磁波暴露造成的垂体-卵巢损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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