The prevalence of presbyphagia in older adults: a systematic review and meta-analysis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-01 Epub Date: 2024-05-01 DOI:10.1007/s00508-024-02366-w

Jianzheng Cai, Zhina Gong, Yingying Zhang, Haifang Wang, Chunyan Niu, Yinuo Dai

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Abstract

Background and objective: Presbyphagia is defined as structural, physiological and innervational alterations in the swallowing process as a result of aging and is considered to be involved in the etiology of dysphagia. This systematic review and meta-analysis aimed to estimate the prevalence of presbyphagia in older adults without disease-related dysphagia.

Methods: In this study five databases were searched in October 2023 with no time limitation. Combined effect sizes of presbyphagia prevalence were calculated using random effect models. Meta-regression and subgroup analyses were conducted to identify sources of heterogeneity. Egger's test and a funnel plot were employed to examine publication bias.

Results: A total of 19 studies were selected for analysis. Overall, the prevalence of presbyphagia in older adults was 30.8% (95% confidence interval [CI] 24.8-36.7%). Publication bias was adjusted for using the fill-and-trim method and the corrected pooled prevalence of presbyphagia was 17.3% (95% CI 11.0-23.6%). In addition, the meta-regression findings revealed that the assessment tool had significant effects upon heterogeneity.

Conclusion: Although the pooled prevalence of presbyphagia in older adults was 17.3%, the lack of large representative studies limited the interpretation of these findings. In the future, further large studies that diagnose presbyphagia using standardized assessment tools would facilitate new avenues to reduce the risk of dysphagia in older adults.

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老年人老花眼的发病率：系统回顾和荟萃分析。

背景和目的：老花吞咽症被定义为因衰老而导致的吞咽过程中的结构、生理和神经改变，并被认为与吞咽困难的病因有关。本系统综述和荟萃分析旨在估算无疾病相关吞咽困难的老年人中老年吞咽困难的患病率：本研究在 2023 年 10 月对五个数据库进行了检索，没有时间限制。使用随机效应模型计算了老花吞咽症患病率的综合效应大小。进行了元回归和亚组分析，以确定异质性的来源。采用 Egger 检验和漏斗图检查发表偏倚：共选择了 19 项研究进行分析。总体而言，老年人老花眼的发病率为 30.8%（95% 置信区间 [CI] 24.8-36.7%）。采用填充和修剪法对发表偏倚进行了调整，校正后的汇总老花眼患病率为 17.3%（95% 置信区间 [CI] 11.0-23.6%）。此外，元回归结果显示，评估工具对异质性有显著影响：尽管老年人老花眼的总体患病率为 17.3%，但由于缺乏具有代表性的大型研究，这些研究结果的解释受到了限制。今后，进一步开展使用标准化评估工具诊断老花吞咽症的大型研究将有助于开辟新的途径，降低老年人吞咽困难的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.