Beneficial Effects of High-Intensity Interval Training and Dietary Changes Intervention on Hepatic Fat Accumulation in HFD-Induced Obese Rats.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-30

X-M Yuan, M-Q Xiang, Y Ping, P-W Zhang, Y-T Liu, X-W Liu, J Wei, Q Tang, Y Zhang

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引用次数: 0

Abstract

Lifestyle intervention encompassing nutrition and physical activity are effective strategies to prevent progressive lipid deposition in the liver. This study aimed to explore the effect of dietary change, and/or high-intensity interval training (HIIT) on hepatic lipid accumulation in high fat diet (HFD)-induced obese rats. We divided lean rats into lean control (LC) or HIIT groups (LH), and obese rats into obese normal chow diet (ND) control (ONC) or HIIT groups (ONH) and obese HFD control (OHC) or HIIT groups (OHH). We found that dietary or HIIT intervention significantly decreased body weight and the risk of dyslipidemia, prevented hepatic lipid accumulation. HIIT significantly improved mitochondrial fatty acid oxidation through upregulating mitochondrial enzyme activities, mitochondrial function and AMPK/PPARalpha/CPT1alpha pathway, as well as inhibiting hepatic de novo lipogenesis in obese HFD rats. These findings indicate that dietary alone or HIIT intervention powerfully improve intrahepatic storage of fat in diet induced obese rats. Keywords: Obesity, Exercise, Diet, Mitochondrial function, Lipid deposition.

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高强度间歇训练和膳食变化干预对高密度脂蛋白诱发肥胖大鼠肝脏脂肪堆积的有益影响

包括营养和体育锻炼在内的生活方式干预是防止肝脏脂质逐渐沉积的有效策略。本研究旨在探讨饮食改变和/或高强度间歇训练（HIIT）对高脂饮食（HFD）诱导的肥胖大鼠肝脏脂质积累的影响。我们将瘦大鼠分为瘦对照组（LC）或 HIIT 组（LH），将肥胖大鼠分为肥胖正常饲料对照组（ONC）或 HIIT 组（ONH）和肥胖高脂饮食对照组（OHC）或 HIIT 组（OHH）。我们发现，饮食或 HIIT 干预能显著降低体重和血脂异常风险，防止肝脏脂质积累。通过上调线粒体酶活性、线粒体功能和 AMPK/PPARalpha/CPT1alpha 通路，HIIT 能明显改善线粒体脂肪酸氧化，并抑制肥胖高密度脂蛋白饮食大鼠的肝脏脂肪新生。这些研究结果表明，单纯饮食或HIIT干预能有效改善饮食诱导肥胖大鼠肝内脂肪储存。关键词肥胖运动饮食线粒体功能脂肪沉积

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.