"Myeloid" Mutations in ALL Are Not Uncommon: Implications for Etiology and Therapies.

IF 11.5 Q1 HEMATOLOGY
Ilaria Iacobucci
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引用次数: 0

Abstract

Summary: In Blood Cancer Discovery, Saygin and colleagues report that somatic variants that are recurrent in myeloid malignancies can also occur with high frequency (16%) in adult acute lymphoblastic leukemia (ALL) where they correlate with older age, diagnosis following genotoxic therapy for a prior malignancy and worse outcome to chemotherapy. Mutations in these "myeloid" genes can precede ALL diagnosis and arise in hematopoietic stem or progenitor cells that clonally expand and differentiate into both lymphoblasts and nonmalignant myeloid cells, supporting a role for clonal hematopoiesis as premalignant state outside the context of myeloid malignancies and providing implications for both ALL etiology and therapeutic intervention. See related article by Saygin et al., p. 164 (4).

ALL 中的 "髓系 "突变并不罕见:对病因学和疗法的影响。
摘要: Saygin及其同事在《血癌发现》(Blood Cancer Discovery)杂志上报告说,在髓系恶性肿瘤中反复出现的体细胞变异也会高频率(16%)地出现在成人急性淋巴细胞白血病(ALL)中,这些变异与年龄偏大、之前的恶性肿瘤经基因毒性治疗后确诊以及化疗效果较差有关。这些 "髓系 "基因的突变可能发生在ALL诊断之前,并出现在造血干细胞或祖细胞中,这些细胞会克隆扩增并分化成淋巴母细胞和非恶性髓系细胞,从而支持克隆造血作为髓系恶性肿瘤之外的恶性前状态的作用,并对ALL的病因学和治疗干预产生影响。参见 Saygin 等人的相关文章,第 164 页(4)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
12.70
自引率
1.80%
发文量
139
期刊介绍: The journal Blood Cancer Discovery publishes high-quality Research Articles and Briefs that focus on major advances in basic, translational, and clinical research of leukemia, lymphoma, myeloma, and associated diseases. The topics covered include molecular and cellular features of pathogenesis, therapy response and relapse, transcriptional circuits, stem cells, differentiation, microenvironment, metabolism, immunity, mutagenesis, and clonal evolution. These subjects are investigated in both animal disease models and high-dimensional clinical data landscapes. The journal also welcomes submissions on new pharmacological, biological, and living cell therapies, as well as new diagnostic tools. They are interested in prognostic, diagnostic, and pharmacodynamic biomarkers, and computational and machine learning approaches to personalized medicine. The scope of submissions ranges from preclinical proof of concept to clinical trials and real-world evidence. Blood Cancer Discovery serves as a forum for diverse ideas that shape future research directions in hematooncology. In addition to Research Articles and Briefs, the journal also publishes Reviews, Perspectives, and Commentaries on topics of broad interest in the field.
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