Association of IGF-1 and IGF-2 genotypes with respiratory muscle strength in individuals with COPD: A cross-sectional study.

IF 1.2 Q2 MEDICINE, GENERAL & INTERNAL

Medwave Pub Date : 2024-04-30 DOI:10.5867/medwave.2024.03.2783

Giovanna de Carvalho, Walter Sepúlveda-Loyola, Luana Oliveira de Lima, Stheace Kelly Fernandes Szezerbaty, Regina Célia Poli-Frederico, Héctor Gutiérrez-Espinoza, Juan José Valenzuela-Fuenzalida, Vanessa Suziane Probst

{"title":"Association of IGF-1 and IGF-2 genotypes with respiratory muscle strength in individuals with COPD: A cross-sectional study.","authors":"Giovanna de Carvalho, Walter Sepúlveda-Loyola, Luana Oliveira de Lima, Stheace Kelly Fernandes Szezerbaty, Regina Célia Poli-Frederico, Héctor Gutiérrez-Espinoza, Juan José Valenzuela-Fuenzalida, Vanessa Suziane Probst","doi":"10.5867/medwave.2024.03.2783","DOIUrl":null,"url":null,"abstract":"Introduction: Chronic obstructive pulmonary disease is a systemic disease characterized not only by respiratory symptoms but also by physical deconditioning and muscle weakness. One prominent manifestation of this disease is the decline in respiratory muscle strength. Previous studies have linked the genotypes of insulin-like growth factor 1 and 2 (IGF-1 and IGF-2) to muscle weakness in other populations without this disease. However, there is a notable knowledge gap regarding the biological mechanisms underlying respiratory muscle weakness, particularly the role of IGF-1 and IGF-2 genotypes in this pulmonary disease. Therefore, this study aimed to investigate, for the first time, the association between IGF-1 and IGF-2 genotypes with respiratory muscle strength in individuals with chronic obstructive pulmonary disease. In addition, we analyzed the relationship between oxidative stress, chronic inflammation, and vitamin D with respiratory muscle strength.Methods: A cross sectional study with 61 individuals with chronic obstructive pulmonary disease. Polymerase chain reaction of gene polymorphisms IGF-1 (rs35767) and IGF-2 (rs3213221) was analyzed. Other variables, related to oxidative stress, inflammation and Vitamin D were dosed from peripheral blood. Maximal inspiratory and expiratory pressure were measured.Results: The genetic polymorphisms were associated with respiratory muscle strength ( 3.0 and 3.5; = 0.57). Specific genotypes of IGF-1 and IGF-2 presented lower maximal inspiratory and expiratory pressure (<0.05 for all). Oxidative stress, inflammatory biomarkers, and vitamin D were not associated with respiratory muscle strength.Conclusion: The polymorphisms of IGF-1 and IGF-2 displayed stronger correlations with respiratory muscle strength compared to blood biomarkers in patients with chronic obstructive pulmonary disease. Specific genotypes of IGF-1 and IGF-2 were associated with reduced respiratory muscle strength in this population.","PeriodicalId":18597,"journal":{"name":"Medwave","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medwave","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5867/medwave.2024.03.2783","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Chronic obstructive pulmonary disease is a systemic disease characterized not only by respiratory symptoms but also by physical deconditioning and muscle weakness. One prominent manifestation of this disease is the decline in respiratory muscle strength. Previous studies have linked the genotypes of insulin-like growth factor 1 and 2 (IGF-1 and IGF-2) to muscle weakness in other populations without this disease. However, there is a notable knowledge gap regarding the biological mechanisms underlying respiratory muscle weakness, particularly the role of IGF-1 and IGF-2 genotypes in this pulmonary disease. Therefore, this study aimed to investigate, for the first time, the association between IGF-1 and IGF-2 genotypes with respiratory muscle strength in individuals with chronic obstructive pulmonary disease. In addition, we analyzed the relationship between oxidative stress, chronic inflammation, and vitamin D with respiratory muscle strength.

Methods: A cross sectional study with 61 individuals with chronic obstructive pulmonary disease. Polymerase chain reaction of gene polymorphisms IGF-1 (rs35767) and IGF-2 (rs3213221) was analyzed. Other variables, related to oxidative stress, inflammation and Vitamin D were dosed from peripheral blood. Maximal inspiratory and expiratory pressure were measured.

Results: The genetic polymorphisms were associated with respiratory muscle strength ( 3.0 and 3.5; = 0.57). Specific genotypes of IGF-1 and IGF-2 presented lower maximal inspiratory and expiratory pressure (<0.05 for all). Oxidative stress, inflammatory biomarkers, and vitamin D were not associated with respiratory muscle strength.

Conclusion: The polymorphisms of IGF-1 and IGF-2 displayed stronger correlations with respiratory muscle strength compared to blood biomarkers in patients with chronic obstructive pulmonary disease. Specific genotypes of IGF-1 and IGF-2 were associated with reduced respiratory muscle strength in this population.

查看原文本刊更多论文

IGF-1 和 IGF-2 基因型与慢性阻塞性肺病患者呼吸肌强度的关系：一项横断面研究。

导言慢性阻塞性肺病是一种全身性疾病，其特征不仅是呼吸系统症状，还包括身体机能减退和肌肉无力。这种疾病的一个突出表现就是呼吸肌力下降。以前的研究已将胰岛素样生长因子 1 和 2（IGF-1 和 IGF-2）的基因型与其他未患此病人群的肌肉无力联系起来。然而，关于呼吸肌无力的生物学机制，尤其是 IGF-1 和 IGF-2 基因型在这种肺部疾病中的作用，还存在明显的知识空白。因此，本研究旨在首次调查 IGF-1 和 IGF-2 基因型与慢性阻塞性肺病患者呼吸肌力量之间的关系。此外，我们还分析了氧化应激、慢性炎症和维生素 D 与呼吸肌强度之间的关系：方法：对 61 名慢性阻塞性肺病患者进行横断面研究。分析了 IGF-1 (rs35767) 和 IGF-2 (rs3213221) 基因多态性的聚合酶链反应。其他与氧化应激、炎症和维生素 D 有关的变量均来自外周血。测量了最大吸气和呼气压力：结果：基因多态性与呼吸肌强度相关（3.0 和 3.5；= 0.57）。IGF-1和IGF-2的特定基因型表现出较低的最大吸气和呼气压力（结论：IGF-1和IGF-2的基因多态性与呼吸肌强度有关：与血液生物标志物相比，IGF-1 和 IGF-2 的多态性与慢性阻塞性肺病患者呼吸肌强度的相关性更强。在这一人群中，IGF-1 和 IGF-2 的特定基因型与呼吸肌强度降低有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Medwave MEDICINE, GENERAL & INTERNAL-

CiteScore

2.60

自引率

8.30%

发文量

审稿时长

12 weeks

期刊介绍： Medwave is a peer-reviewed, biomedical and public health journal. Since its foundation in 2001 (Volume 1) it has always been an online only, open access publication that does not charge subscription or reader fees. Since January 2011 (Volume 11, Number 1), all articles are peer-reviewed. Without losing sight of the importance of evidence-based approach and methodological soundness, the journal accepts for publication articles that focus on providing updates for clinical practice, review and analysis articles on topics such as ethics, public health and health policy; clinical, social and economic health determinants; clinical and health research findings from all of the major disciplines of medicine, medical science and public health. The journal does not publish basic science manuscripts or experiments conducted on animals. Until March 2013, Medwave was publishing 11-12 numbers a year. Each issue would be posted on the homepage on day 1 of each month, except for Chile’s summer holiday when the issue would cover two months. Starting from April 2013, Medwave adopted the continuous mode of publication, which means that the copyedited accepted articles are posted on the journal’s homepage as they are ready. They are then collated in the respective issue and included in the Past Issues section.