Comparison of the Friedewald and Vujovic methods with the calculated LDL concentration in a biochemical auto-analyzer.

IF 1.2 Q2 MEDICINE, GENERAL & INTERNAL

Medwave Pub Date : 2024-05-06 DOI:10.5867/medwave.2024.04.2775

Jaime Rosales-Rimache, Jeisson Apaza-Condori, Jhonatan Rabanal-Sanchez, Li Jari, Fernando Soncco-Llulluy

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引用次数: 0

Abstract

Objective: To compare the concentration of Low-Density Lipoprotein (LDL-c) obtained using the Friedewald formula with those obtained directly with the RAYTO CHEMRAY 120 autoanalyzer.

Methods: Cross-sectional study. We evaluated outpatients with a medical request for a lipid profile study (total cholesterol, triglycerides, LDL, and HDL). The analyses were carried out in a RAYTO CHEMRAY 120 autoanalyzer under the principle of spectrophotometry. We obtained LDL-c using the Friedewald and Vujovic formulas.

Results: We evaluated 199 individuals whose direct LDL concentration averages were measured by the RAYTO CHEMRAY 120 equipment. Those calculated by the Friedewald and Vujovic formulas were 129.97 ± 32.66, 119.28 ± 30.44, and 127.01 ± 32.01, respectively, and in all cases, significant differences (P < 0.001) were observed with the RAYTO analyzer. In both cases a low positive bias was found with the RAYTO analyzer.. The Passing-Bablok and Deming's regressions showed a linear correlation between both methods (Friedewald and Vujovic) with the LDL values obtained with the Rayto autoanalyzer.

Conclusions: Our study found that the Friedewald and Vujovic methods are good predictors of LDL cholesterol levels and have a low level of bias. Therefore, they could be used as potential predictors.

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弗里德瓦尔德法和武约维奇法与生化自动分析仪计算出的低密度脂蛋白浓度的比较。

目的：比较使用弗里德瓦尔德公式得出的低密度脂蛋白（LDL-c）浓度与直接使用 RAYTO CHEMRAY 120 自动分析仪得出的浓度：比较使用弗里德瓦尔德公式得出的低密度脂蛋白（LDL-c）浓度与使用 RAYTO CHEMRAY 120 自动分析仪直接得出的低密度脂蛋白（LDL-c）浓度：横断面研究。我们对有血脂检查（总胆固醇、甘油三酯、低密度脂蛋白和高密度脂蛋白）医疗要求的门诊患者进行了评估。分析是在 RAYTO CHEMRAY 120 自动分析仪上根据分光光度法原理进行的。我们使用弗里德瓦尔德公式和武约维奇公式计算出低密度脂蛋白胆固醇：我们对使用 RAYTO CHEMRAY 120 设备直接测量低密度脂蛋白浓度平均值的 199 人进行了评估。根据弗里德瓦尔德公式和武约维奇公式计算出的平均值分别为 129.97 ± 32.66、119.28 ± 30.44 和 127.01 ± 32.01，在所有情况下，与 RAYTO 分析仪都有显著差异（P < 0.001）。在这两种情况下，RAYTO 分析仪都发现了较低的正偏差。Passing-Bablok和Deming回归显示，两种方法（Friedewald和Vujovic）与RAYTO自动分析仪获得的低密度脂蛋白值之间存在线性相关：我们的研究发现，弗里德瓦尔德法和武约维奇法能很好地预测低密度脂蛋白胆固醇水平，而且偏差较小。因此，它们可用作潜在的预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medwave MEDICINE, GENERAL & INTERNAL-

CiteScore

2.60

自引率

8.30%

发文量

审稿时长

12 weeks

期刊介绍： Medwave is a peer-reviewed, biomedical and public health journal. Since its foundation in 2001 (Volume 1) it has always been an online only, open access publication that does not charge subscription or reader fees. Since January 2011 (Volume 11, Number 1), all articles are peer-reviewed. Without losing sight of the importance of evidence-based approach and methodological soundness, the journal accepts for publication articles that focus on providing updates for clinical practice, review and analysis articles on topics such as ethics, public health and health policy; clinical, social and economic health determinants; clinical and health research findings from all of the major disciplines of medicine, medical science and public health. The journal does not publish basic science manuscripts or experiments conducted on animals. Until March 2013, Medwave was publishing 11-12 numbers a year. Each issue would be posted on the homepage on day 1 of each month, except for Chile’s summer holiday when the issue would cover two months. Starting from April 2013, Medwave adopted the continuous mode of publication, which means that the copyedited accepted articles are posted on the journal’s homepage as they are ready. They are then collated in the respective issue and included in the Past Issues section.