A study of inflammatory biomarkers in crystalline silica exposed rock drillers.

IF 2.6 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Archives of Occupational and Environmental Health Pub Date : 2024-07-01 Epub Date: 2024-05-04 DOI:10.1007/s00420-024-02070-2

Dag G Ellingsen, Liv Ingunn Bjoner Sikkeland, May Britt Lund, Nils Petter Skaugset, Bente Ulvestad

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引用次数: 0

Abstract

Background: Crystalline silica (CS) exposure can cause serious lung disease in humans, but mechanisms of pulmonary toxicity have not been completely elucidated.

Aims: To assess pro-inflammatory and anti-inflammatory biomarkers and biomarkers related to the development of chronic obstructive pulmonary disease and fibrosis in serum of rock drillers exposed to CS.

Methods: Rock drillers (N = 123) exposed to CS and non-specified particulate matter (PM) were compared to 48 referents without current or past exposure to PM in a cross-sectional study.

Results: The rock drillers had been exposed to CS for 10.7 years on average. Geometric mean (GM) current exposure was estimated to 36 µg/m³. Their GM concentration of matrix metalloproteinase 12 (MMP-12) was significantly higher (16 vs. 13 ng/L; p = 0.04), while interleukin (IL) 6 and IL-8 were significantly lower compared to the referents. Also pentraxin 3 was significantly lower (3558 vs. 4592 ng/L; p = 0.01) in the rock drillers. A dose-response relationship was observed between cumulative exposure to CS and MMP-12, the highest exposed subgroup having significantly higher MMP-12 concentrations than the referents.

Conclusion: Exposure to CS may increase circulating MMP-12 concentrations in a dose-response related fashion. The results may also suggest a down-regulation of pro-inflammatory pathways.

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晶体硅暴露于凿岩机中的炎症生物标志物研究。

背景：目的：评估暴露于二氧化硅（CS）的凿岩工人血清中的促炎和抗炎生物标志物以及与慢性阻塞性肺病和纤维化发展相关的生物标志物：在一项横断面研究中，将暴露于CS和非特定颗粒物（PM）的凿岩工人（N = 123）与48名目前或过去未暴露于PM的参照者进行比较：凿岩工人接触 CS 的时间平均为 10.7 年。目前接触的几何平均（GM）浓度估计为 36 µg/m3。与参照者相比，他们的基质金属蛋白酶 12 (MMP-12) 的 GM 浓度明显较高（16 对 13 ng/L；p = 0.04），而白细胞介素 (IL) 6 和 IL-8 则明显较低。此外，凿岩工人的五胜肽 3 也明显较低（3558 对 4592 ng/L；p = 0.01）。CS的累积暴露量与MMP-12之间存在剂量反应关系，暴露量最高的亚组的MMP-12浓度明显高于参照组：结论：暴露于 CS 可能会增加循环中的 MMP-12 浓度，且与剂量反应相关。结论：暴露于 CS 可能会以剂量-反应相关的方式增加循环中 MMP-12 的浓度，其结果也可能表明促炎通路被下调。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.60

自引率

6.70%

发文量

127

审稿时长

3 months

期刊介绍： International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.