Smoking and Idiopathic Pulmonary Fibrosis: A Meta-analysis.

IF 3 2区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Nicotine & Tobacco Research Pub Date : 2024-11-22 DOI:10.1093/ntr/ntae100

Min Fang, Bixiu He, Jian Xiao

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引用次数: 0

Abstract

Introduction: In this study, we aimed to systematically explore the relationship between smoking and idiopathic pulmonary fibrosis (IPF).

Aims and methods: The PubMed, Web of Science, and Embase databases were searched to systematically identify eligible studies. The Newcastle‒Ottawa Quality Assessment Scale (NOS) was used to evaluate the quality of the selected studies. The pooled odds ratio (OR) and survival hazard ratio (HR) were calculated with a random effects model using Stata 16.0 software.

Results: Thirty studies were enrolled. All of the included studies were considered to have intermediate or high quality. Nine studies were suitable for meta-analysis of ORs, and 21 studies were suitable for meta-analysis of survival HR. The pooled analysis revealed a significant difference in the risk of IPF between the smoking group and the never-smoking group (OR 1.71, 95% CI: 1.27 to 2.30, p < .001), indicating that smoking is a risk factor for IPF. When analyzing pooled survival HRs, never smoking was compared to former smoking or current smoking. Former smoking was shown to be a poor prognostic factor for IPF (HR 1.43, 95% CI: 1.18 to 1.74, p < .001), but current smoking was not a significant factor.

Conclusions: Our results indicated that smoking is a risk factor for IPF patients.

Implications: In this study, we mainly concluded that smoking is a risk factor for IPF and that former smoking is a poor prognostic factor for IPF. To the best of our knowledge, this is the first meta-analysis report focusing on the association between smoking per se and IPF. Through our current study, we hope to further raise awareness of the relationship between smoking and IPF.

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吸烟与特发性肺纤维化：荟萃分析

简介：本研究旨在系统探讨吸烟与特发性肺纤维化（IPF）之间的关系：本研究旨在系统探讨吸烟与特发性肺纤维化（IPF）之间的关系：方法：我们对 PubMed、Web of Science 和 Embase 数据库进行了检索，以系统地确定符合条件的研究。采用纽卡斯尔-渥太华质量评估量表（NOS）评估所选研究的质量。使用Stata 16.0软件的随机效应模型计算了汇总的几率比（OR）和生存危险比（HR）：共纳入 30 项研究。所有纳入的研究均被认为具有中等或较高的质量。9项研究适合进行ORs的荟萃分析，21项研究适合进行生存HR的荟萃分析。汇总分析表明，吸烟组和从不吸烟组之间罹患 IPF 的风险存在显著差异（OR 1.71，95% CI 1.27-2.30，P <0.001），表明吸烟是 IPF 的一个风险因素。在分析汇总生存率时，将从不吸烟与曾经吸烟或目前吸烟进行了比较。结果表明，曾经吸烟是IPF的不良预后因素（HR 1.43，95% CI 1.18-1.74，P < 0.001），但目前吸烟并不是一个重要因素：结论：我们的研究结果表明，吸烟是IPF患者的一个危险因素：本研究的主要结论是，吸烟是 IPF 的一个危险因素，而曾经吸烟是 IPF 的一个不良预后因素。据我们所知，这是第一份关注吸烟本身与 IPF 关联的荟萃分析报告。我们希望通过本次研究，进一步提高人们对吸烟与 IPF 之间关系的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nicotine & Tobacco Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

8.10

自引率

10.60%

发文量

268

审稿时长

3-8 weeks

期刊介绍： Nicotine & Tobacco Research is one of the world''s few peer-reviewed journals devoted exclusively to the study of nicotine and tobacco. It aims to provide a forum for empirical findings, critical reviews, and conceptual papers on the many aspects of nicotine and tobacco, including research from the biobehavioral, neurobiological, molecular biologic, epidemiological, prevention, and treatment arenas. Along with manuscripts from each of the areas mentioned above, the editors encourage submissions that are integrative in nature and that cross traditional disciplinary boundaries. The journal is sponsored by the Society for Research on Nicotine and Tobacco (SRNT). It publishes twelve times a year.