A comparative study of ceftazidime/avibactam-based and fosfomycin plus meropenem-based regimens for managing infections caused by carbapenem-resistant Klebsiella pneumoniae in critically ill patients.

IF 1.9 4区医学 Q3 INFECTIOUS DISEASES

Journal of Chemotherapy Pub Date : 2025-02-01 Epub Date: 2024-05-03 DOI:10.1080/1120009X.2024.2349439

Uğur Önal, Ülkü Tüzemen, Pınar Küçükdemirci Kaya, Remzi İşçimen, Nermin Kelebek Girgin, Cüneyt Özakın, Ferda Kahveci, Halis Akalın

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引用次数: 0

Abstract

The main aim of this study was to compare and analyze the effectiveness of treatment regimens using ceftazidime/avibactam (CAZ/AVI) versus fosfomycin plus meropenem (FOS/MER) for managing bloodstream infections (BSI) or ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) in critically ill patients. Between 4 January 2019, and 16 July 2023, adult patients (≥18 years old) diagnosed with BSI or VAP due to culture confirmed CRKP in ICU of a tertiary care hospital were investigated retrospectively. A total of 71 patients were categorized into two groups: 30 patients in CAZ/AVI-based, and 41 patients in FOS/MER-based group. No substantial disparities were found in the total duration of ICU hospitalization, as well as the 14- and 30-day mortality rates, between patients treated with CAZ/AVI-based and FOS/MER-based therapeutic regimens. We consider that our study provides for the first time a comprehensive understanding of treatment outcomes and associated risk factors among patients with CRKP-related infections.

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以头孢唑肟/阿维菌素为基础和以磷霉素加美罗培南为基础的方案治疗重症患者耐碳青霉烯类肺炎克雷伯氏菌感染的比较研究。

本研究的主要目的是比较和分析使用头孢唑肟/阿维菌素（CAZ/AVI）与福斯霉素加美罗培南（FOS/MER）治疗方案对重症患者耐碳青霉烯类肺炎克雷伯菌（CRKP）引起的血流感染（BSI）或呼吸机相关性肺炎（VAP）的疗效。在2019年1月4日至2023年7月16日期间，对一家三甲医院重症监护室中因培养证实的CRKP而确诊为BSI或VAP的成年患者（≥18岁）进行了回顾性调查。共有 71 名患者被分为两组：30 名患者以 CAZ/AVI 为基础，41 名患者以 FOS/MER 为基础。结果发现，采用 CAZ/AVI 治疗方案和 FOS/MER 治疗方案的患者在重症监护室的总住院时间以及 14 天和 30 天死亡率方面没有明显差异。我们认为，我们的研究首次全面了解了 CRKP 相关感染患者的治疗结果和相关风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Chemotherapy 医学-药学

CiteScore

3.70

自引率

0.00%

发文量

144

审稿时长

6-12 weeks

期刊介绍： The Journal of Chemotherapy is an international multidisciplinary journal committed to the rapid publication of high quality, peer-reviewed, original research on all aspects of antimicrobial and antitumor chemotherapy. The Journal publishes original experimental and clinical research articles, state-of-the-art reviews, brief communications and letters on all aspects of chemotherapy, providing coverage of the pathogenesis, diagnosis, treatment, and control of infection, as well as the use of anticancer and immunomodulating drugs. Specific areas of focus include, but are not limited to: · Antibacterial, antiviral, antifungal, antiparasitic, and antiprotozoal agents; · Anticancer classical and targeted chemotherapeutic agents, biological agents, hormonal drugs, immunomodulatory drugs, cell therapy and gene therapy; · Pharmacokinetic and pharmacodynamic properties of antimicrobial and anticancer agents; · The efficacy, safety and toxicology profiles of antimicrobial and anticancer drugs; · Drug interactions in single or combined applications; · Drug resistance to antimicrobial and anticancer drugs; · Research and development of novel antimicrobial and anticancer drugs, including preclinical, translational and clinical research; · Biomarkers of sensitivity and/or resistance for antimicrobial and anticancer drugs; · Pharmacogenetics and pharmacogenomics; · Precision medicine in infectious disease therapy and in cancer therapy; · Pharmacoeconomics of antimicrobial and anticancer therapies and the implications to patients, health services, and the pharmaceutical industry.