A systematic review of the beneficial effects of prebiotics, probiotics, and synbiotics on ADHD.

IF 2 Q3 NEUROSCIENCES

Neuropsychopharmacology Reports Pub Date : 2024-06-01 Epub Date: 2024-04-16 DOI:10.1002/npr2.12437

Pooneh Allahyari, Saheb Abbas Torki, Bahareh Aminnezhad Kavkani, Zahra Mahmoudi, Mohadeseh Sadat Mousavi Hoseini, Mahdi Moradi, Farkhondeh Alami, Mohammad Keshavarz Mohammadian, Samira Bahoo Sele Bani, Khadijeh Abbasi Mobarakeh, Hanieh Shafaei, Sara Khoshdooz, Azadeh Hajipour, Saeid Doaei, Maryam Gholamalizadeh

{"title":"A systematic review of the beneficial effects of prebiotics, probiotics, and synbiotics on ADHD.","authors":"Pooneh Allahyari, Saheb Abbas Torki, Bahareh Aminnezhad Kavkani, Zahra Mahmoudi, Mohadeseh Sadat Mousavi Hoseini, Mahdi Moradi, Farkhondeh Alami, Mohammad Keshavarz Mohammadian, Samira Bahoo Sele Bani, Khadijeh Abbasi Mobarakeh, Hanieh Shafaei, Sara Khoshdooz, Azadeh Hajipour, Saeid Doaei, Maryam Gholamalizadeh","doi":"10.1002/npr2.12437","DOIUrl":null,"url":null,"abstract":"Background: Children with attention deficit hyperactivity disorder (ADHD) may benefit from probiotics and prebiotics, but the effects are unclear. To determine whether probiotics and prebiotics affect children with ADHD, a systematic review was conducted.Methods: The present systematic review analyzed cohort studies and randomized controlled trials that examined whether prebiotics and probiotics are associated with ADHD. Seven randomized controlled trials and two cohort studies met our inclusion criteria.Results: Research on Lactobacillus rhamnosus GG (LGG) probiotic supplementation showed that children with ADHD had better emotional, physical, social, and school functioning, and a higher health-related quality of life compared to the placebo group. The studies also showed that Synbiotic 2000 reduces markers of intestinal and vascular inflammation in children with ADHD, in part through increasing SCFA levels.Conclusion: The use of probiotics and prebiotics as adjuvants therapy in patients with ADHD is beneficial. Further studies with longer duration, including more participants and a variety of age groups, and using various evaluation techniques such as in vivo observation are required to examine the effects of prebiotics and probiotics on ADHD.","PeriodicalId":19137,"journal":{"name":"Neuropsychopharmacology Reports","volume":" ","pages":"300-307"},"PeriodicalIF":2.0000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11144606/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuropsychopharmacology Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/npr2.12437","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/4/16 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Children with attention deficit hyperactivity disorder (ADHD) may benefit from probiotics and prebiotics, but the effects are unclear. To determine whether probiotics and prebiotics affect children with ADHD, a systematic review was conducted.

Methods: The present systematic review analyzed cohort studies and randomized controlled trials that examined whether prebiotics and probiotics are associated with ADHD. Seven randomized controlled trials and two cohort studies met our inclusion criteria.

Results: Research on Lactobacillus rhamnosus GG (LGG) probiotic supplementation showed that children with ADHD had better emotional, physical, social, and school functioning, and a higher health-related quality of life compared to the placebo group. The studies also showed that Synbiotic 2000 reduces markers of intestinal and vascular inflammation in children with ADHD, in part through increasing SCFA levels.

Conclusion: The use of probiotics and prebiotics as adjuvants therapy in patients with ADHD is beneficial. Further studies with longer duration, including more participants and a variety of age groups, and using various evaluation techniques such as in vivo observation are required to examine the effects of prebiotics and probiotics on ADHD.

查看原文本刊更多论文

关于益生元、益生菌和合成益生元对多动症有益影响的系统性综述。

背景：患有注意力缺陷多动障碍（ADHD）的儿童可能会从益生菌和益生元中获益，但其效果尚不明确。为了确定益生菌和益生元是否会对多动症儿童产生影响，我们进行了一项系统性综述：本系统综述分析了研究益生菌和益生元是否与多动症有关的队列研究和随机对照试验。七项随机对照试验和两项队列研究符合我们的纳入标准：结果：有关鼠李糖乳杆菌 GG（LGG）益生菌补充剂的研究表明，与安慰剂组相比，多动症儿童的情绪、身体、社交和学校功能更好，与健康相关的生活质量更高。研究还表明，"合成益生菌 2000 "能降低多动症儿童肠道和血管炎症指标，部分原因是它能提高 SCFA 水平：结论：使用益生菌和益生元作为多动症患者的辅助疗法是有益的。需要进行持续时间更长、参与人数更多和年龄组更多样的进一步研究，并使用各种评估技术（如体内观察）来研究益生菌和益生元对多动症的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊