Human cat borne rabies as the new epidemiology of the disease in the Andes mountains

IF 2.4 2区农林科学 Q3 INFECTIOUS DISEASES

Zoonoses and Public Health Pub Date : 2024-05-05 DOI:10.1111/zph.13141

Samir Meriño-Olivella, María del Pilar Sánchez-Bonilla, Luis E. Escobar, Nathalia M. Correa-Valencia

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引用次数: 0

Abstract

Background

Rabies virus (RABV) is the etiologic agent of rabies, a fatal brain disease in mammals. Rabies circulation has historically involved the dog has the main source of human rabies worldwide. Nevertheless, in Colombia, cats (Felis catus) have become a relevant species in the epidemiology of rabies.

Aims

To characterize rabies cases in humans in Colombia in the last three decades in the context of the epidemiology of the aggressor animal.

Materials and Methods

We conducted a retrospective longitudinal epidemiological study of human rabies caused by cats’ aggression, collecting primary and secondary information. Variables considered included the demography of the patient, symptoms, information about the aggressor animal as the source of infection and the viral variant identified.

Results

We found that the distribution of rabies incidence over the years has been constant in Colombia. Nevertheless, between 2003 and 2012 a peak of cases occurred in rural Colombia where cats were the most frequent aggressor animal reported. Most cats involved in aggression were unvaccinated against rabies. Cat's clinical signs at the time of the report of the human cases included hypersalivation and changes in behaviour. Human patients were mostly children and female and the exposure primarily corresponded to bite and puncture lacerations in hands. The RABV lineage detected in most cases corresponded to variant 3, linked to the common vampire bat (Desmodus rotundus). The geographical presentation of cat borne RABV in humans occurred along the Andes mountains, epidemiologically known as the rabies red Andean corridor.

Discussion

By finding cats as the primary source of rabies spillover transmission in Colombia, this report highlights the importance of revising national rabies control and prevention protocol in countries in the Andes region.

Conclusion

Our results demonstrate that rabies vaccination for outdoor cats needs to prioritize to reduce the number of rabies-related human deaths.

查看原文本刊更多论文

人猫共患狂犬病是安第斯山脉的新流行病学。

背景：狂犬病病毒（RABV）是狂犬病的病原体，狂犬病是哺乳动物中一种致命的脑部疾病。在全球范围内，狂犬病的主要传染源一直是狗。然而，在哥伦比亚，猫（Felis catus）已成为狂犬病流行病学中的一个相关物种。目的：结合侵害动物的流行病学，描述过去三十年哥伦比亚人类狂犬病病例的特征：我们对猫的攻击行为导致的人类狂犬病进行了一项回顾性纵向流行病学研究，收集了主要和次要信息。考虑的变量包括患者的人口统计学特征、症状、作为传染源的侵害动物的信息以及确定的病毒变种：我们发现，哥伦比亚狂犬病发病率的分布多年来一直保持不变。然而，2003年至2012年期间，哥伦比亚农村地区的病例数达到高峰，猫是最常见的侵害动物。大多数参与攻击的猫都未接种狂犬病疫苗。在报告人类病例时，猫的临床症状包括唾液分泌过多和行为改变。人类患者多为儿童和女性，主要是被咬伤和手部刺伤。在大多数病例中检测到的 RABV 株系与变异 3 相符，与常见的吸血蝙蝠（Desmodus rotundus）有关。猫传播的 RABV 在人类中的地理分布是沿安第斯山脉，在流行病学上被称为狂犬病红色安第斯走廊：讨论：通过发现猫是哥伦比亚狂犬病外溢传播的主要来源，本报告强调了安第斯地区国家修订国家狂犬病控制和预防方案的重要性：我们的研究结果表明，需要优先为户外猫接种狂犬病疫苗，以减少与狂犬病相关的人类死亡人数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zoonoses and Public Health 医学-传染病学

CiteScore

5.30

自引率

4.20%

发文量

115

审稿时长

6-12 weeks

期刊介绍： Zoonoses and Public Health brings together veterinary and human health researchers and policy-makers by providing a venue for publishing integrated and global approaches to zoonoses and public health. The Editors will consider papers that focus on timely collaborative and multi-disciplinary research in zoonoses and public health. This journal provides rapid publication of original papers, reviews, and potential discussion papers embracing this collaborative spirit. Papers should advance the scientific knowledge of the sources, transmission, prevention and control of zoonoses and be authored by scientists with expertise in areas such as microbiology, virology, parasitology and epidemiology. Articles that incorporate recent data into new methods, applications, or approaches (e.g. statistical modeling) which enhance public health are strongly encouraged.