Emerging roles of RNA-binding proteins in fatty liver disease.

IF 6.4 2区 生物学 Q1 CELL BIOLOGY
Oluwafolajimi Adesanya, Diptatanu Das, Auinash Kalsotra
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引用次数: 0

Abstract

A rampant and urgent global health issue of the 21st century is the emergence and progression of fatty liver disease (FLD), including alcoholic fatty liver disease and the more heterogenous metabolism-associated (or non-alcoholic) fatty liver disease (MAFLD/NAFLD) phenotypes. These conditions manifest as disease spectra, progressing from benign hepatic steatosis to symptomatic steatohepatitis, cirrhosis, and, ultimately, hepatocellular carcinoma. With numerous intricately regulated molecular pathways implicated in its pathophysiology, recent data have emphasized the critical roles of RNA-binding proteins (RBPs) in the onset and development of FLD. They regulate gene transcription and post-transcriptional processes, including pre-mRNA splicing, capping, and polyadenylation, as well as mature mRNA transport, stability, and translation. RBP dysfunction at every point along the mRNA life cycle has been associated with altered lipid metabolism and cellular stress response, resulting in hepatic inflammation and fibrosis. Here, we discuss the current understanding of the role of RBPs in the post-transcriptional processes associated with FLD and highlight the possible and emerging therapeutic strategies leveraging RBP function for FLD treatment. This article is categorized under: RNA in Disease and Development > RNA in Disease.

RNA 结合蛋白在脂肪肝中的新作用。
脂肪肝(FLD),包括酒精性脂肪肝和代谢相关性(或非酒精性)脂肪肝(MAFLD/NAFLD)表型,是 21 世纪一个猖獗而紧迫的全球健康问题。这些病症表现为疾病谱,从良性肝脂肪变性发展为无症状脂肪性肝炎、肝硬化,最终发展为肝细胞癌。FLD 的病理生理学涉及许多错综复杂的分子调控途径,最近的数据强调了 RNA 结合蛋白(RBPs)在 FLD 发病和发展过程中的关键作用。它们调控基因转录和转录后过程,包括前 mRNA 剪接、加盖和多聚腺苷酸化,以及成熟 mRNA 的转运、稳定性和翻译。在 mRNA 生命周期的每个阶段,RBP 功能障碍都与脂质代谢和细胞应激反应的改变有关,从而导致肝脏炎症和纤维化。在此,我们将讨论目前对 RBP 在与 FLD 相关的转录后过程中的作用的理解,并重点介绍利用 RBP 功能治疗 FLD 的可能和新兴治疗策略。本文归类于疾病与发育中的 RNA > 疾病中的 RNA。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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