Analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as inflammatory biomarkers in chronic kidney disease: impact of parathyroidectomy.

IF 1.3 Q3 UROLOGY & NEPHROLOGY
Andre Kakinoki Teng, Eduardo Jorge Duque, Shirley Ferraz Crispilho, Wagner Domingues, Vanda Jorgetti, Luciene M Dos Reis, Rosilene M Elias, Rosa Maria Affonso Moysés
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引用次数: 0

Abstract

Introduction: Secondary hyperparathyroidism (SHPT) is one of the causes for inflammation in CKD. We assessed the impact of parathyroidectomy (PTX) on neutrophil-to-lymphocyte (N/L) and platelet-to-lymphocyte (P/L) ratios in SHPT patients.

Methods: A total of 118 patients [hemodialysis (HD, n = 81), and transplant recipients (TX, n = 37)] undergoing PTX between 2015 and 2021 were analyzed.

Results: There was a significant reduction in calcium and PTH levels in both groups, in addition to an increase in vitamin D. In the HD group, PTX did not alter N/L and P/L ratios. In the TX group, there was a reduction in N/L and P/L ratios followed by a significant increase in total lymphocyte count.

Conclusion: N/L and P/L ratios are not reliable biomarkers of inflammation in SHPT patients undergoing PTX. Uremia, which induces a state of chronic inflammation in dialysis patients, and the use of immunosuppression in kidney transplant recipients are some of the confounding factors that prevent the use of this tool in clinical practice.

分析作为慢性肾脏病炎症生物标志物的中性粒细胞对淋巴细胞比率和血小板对淋巴细胞比率:甲状旁腺切除术的影响。
简介继发性甲状旁腺功能亢进症(SHPT)是导致慢性肾脏病炎症的原因之一。我们评估了甲状旁腺切除术(PTX)对SHPT患者中性粒细胞对淋巴细胞(N/L)和血小板对淋巴细胞(P/L)比率的影响:分析了2015年至2021年期间接受PTX治疗的118名患者[血液透析(HD,n = 81)和移植受者(TX,n = 37)]:两组患者的钙和PTH水平均明显下降,维生素D水平也有所上升。在TX组,N/L和P/L比率降低,但总淋巴细胞数显著增加:结论:在接受 PTX 治疗的 SHPT 患者中,N/L 和 P/L 比率不是可靠的炎症生物标志物。尿毒症会诱发透析患者的慢性炎症状态,肾移植受者使用免疫抑制剂也是妨碍在临床实践中使用该工具的一些干扰因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.20
自引率
16.70%
发文量
208
审稿时长
16 weeks
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