Family History of Type 2 Diabetes and Its Association with Beta Cell Function and Lipid Profile in Newly Diagnosed Pediatric Patients with Type 1 Diabetes.

IF 1.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrine Research Pub Date : 2024-02-01 Epub Date: 2024-04-26 DOI:10.1080/07435800.2024.2339934

Dan Chi, Mingqiang Zhu, Guanping Dong, Hui Gao, Wenqing Xiang, Qing Ye, Junfen Fu

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引用次数: 0

Abstract

Objective: The objective of this study was to explore the associations between a family history of type 2 diabetes (T2D) and beta-cell function, as well as lipid profile, in pediatric patients newly diagnosed with type 1 diabetes (T1D).

Methods: A retrospective analysis was conducted on children under 14 years of age who were newly diagnosed with T1D at the Children's Hospital of Zhejiang University between August 2018 and August 2022. Clinical features, metabolic profiles, beta-cell function, and lipid profile were evaluated.

Results: A total of 316 children were diagnosed with new-onset T1D. Among them, 28.2% had a family history of T2D. Patients with T1D who had a family history of T2D experienced a later onset of the disease (p = 0.016), improved HOMA2-%B levels (p = 0.003), and increased concentrations of HDL-C (p = 0.005). In addition, no statistically significant differences in age at onset, HOMA2-%B levels, or HDL-C were found when assessing the interaction between family history of T2D and type of diabetes mellitus (autoimmune T1D/idiopathic T1D).

Conclusion: A family history of T2D may contribute to the heterogeneity of T1D patients in terms of HOMA2-%B levels and lipid profile. This highlights the significance of taking into account T2D-related factors in the diagnosis and treatment of T1D.

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2型糖尿病家族史及其与新诊断的1型糖尿病儿童患者β细胞功能和血脂谱的关系。

研究目的本研究旨在探讨新诊断为1型糖尿病（T1D）的儿童患者的2型糖尿病（T2D）家族史与β细胞功能以及血脂谱之间的关联：对2018年8月至2022年8月期间在浙江大学附属儿童医院新诊断为T1D的14岁以下儿童进行回顾性分析。结果：共有316名儿童被诊断为T1D：共有 316 名儿童被诊断为新发 T1D。结果：共有 316 名儿童被诊断为新发 T1D，其中 28.2% 有 T2D 家族史。有 T2D 家族史的 T1D 患者起病较晚（p = 0.016），HOMA2-%B 水平有所提高（p = 0.003），高密度脂蛋白胆固醇浓度有所增加（p = 0.005）。此外，在评估T2D家族史与糖尿病类型（自身免疫性T1D/特发性T1D）之间的相互作用时，发现发病年龄、HOMA2-%B水平或高密度脂蛋白胆固醇在统计学上没有显著差异：结论：T2D家族史可能导致T1D患者在HOMA2-%B水平和血脂谱方面的异质性。这凸显了在诊断和治疗 T1D 时考虑 T2D 相关因素的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.