Relationship of serum and dietary vitamin D with high cardiometabolic risk in Mexican systemic lupus erythematosus patients: A cross-sectional study.

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2024-07-01 Epub Date: 2024-05-06 DOI:10.1177/09612033241252060
Adolfo I Ruiz-Ballesteros, Alejandra Betancourt-Núñez, Mónica R Meza-Meza, Melissa Rivera-Escoto, Paulina E Mora-García, Karen Pesqueda-Cendejas, Barbara Vizmanos, Isela Parra-Rojas, Bertha Campos-López, Margarita Montoya-Buelna, Sergio Cerpa-Cruz, Ulises De la Cruz-Mosso
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Abstract

Objetive: Serum and dietary vitamin D could influence clinical disease activity and cardiometabolic outcomes in systemic lupus erythematosus (SLE). This study aimed to assess the relationship of serum and dietary vitamin D with cardiometabolic risk in Mexican SLE patients and healthy subjects (HS).Methods: 224 SLE patients and 201 HS were included in this cross-sectional study. Serum calcidiol was measured using a competitive enzyme-linked immunosorbent assay (ELISA). Vitamin D dietary intake was assessed by collecting three 24h food records. Dietary patterns (DPs) were identified using principal component analysis (PCA). Cardiometabolic status was analyzed through biochemical measurements and cardiometabolic indexes.Results: Calcidiol deficiency (<20 ng/mL) was associated with 1.66-fold higher risk of excess weight by body mass index (BMI) (≥25 kg/m2) (p = .02), 2.25-fold higher risk to low high-density lipoprotein-cholesterol (HDL-C) (<40 mg/dL) (p < .001), and 1.74-fold higher risk to high triglycerides (TG) ≥150 mg/dL (p = .02). Inadequate vitamin D dietary intake was associated with 1.92-fold higher risk of presenting non-healthy waist circumference (WC) (>80 cm) (p < .01), 2.05-fold higher risk of android waist to hip ratio (WHR ≥85) (p < .01), and 1.72-fold higher risk to excess weight (p = .02). Non-adherence to a DP rich in vitamin D food sources was associated with higher WC, WHR, triglycerides, and lower high-density lipoprotein-cholesterol (HDL-C); furthermore, in HS, non-adherence to the DP rich in vitamin D food sources provided 2.11-fold higher risk to calcidiol deficiency.In Cconclusion: A pattern of Calcidiol deficiency, inadequate vitamin D dietary intake, and non-adherence to a DP rich in vitamin D food sources was related to high cardiometabolic risk in SLE patients and HS.

墨西哥系统性红斑狼疮患者血清和膳食维生素 D 与高心脏代谢风险的关系:一项横断面研究。
目的血清和膳食维生素D可影响系统性红斑狼疮(SLE)的临床疾病活动和心脏代谢结果。本研究旨在评估墨西哥系统性红斑狼疮患者和健康受试者(HS)的血清和膳食维生素 D 与心脏代谢风险之间的关系。采用竞争性酶联免疫吸附测定法(ELISA)测量血清中的钙化二醇。通过收集三份 24 小时食物记录来评估维生素 D 的膳食摄入量。采用主成分分析法(PCA)确定膳食模式(DP)。通过生化测量和心脏代谢指数分析心脏代谢状况:钙二醇缺乏症(80 厘米)(p < .01),甲状腺腰臀比(WHR ≥85)风险高 2.05 倍(p < .01),超重风险高 1.72 倍(p = .02)。不坚持摄入富含维生素 D 的食物来源与较高的腰围、WHR、甘油三酯和较低的高密度脂蛋白胆固醇(HDL-C)有关;此外,在 HS 中,不坚持摄入富含维生素 D 的食物来源会使降钙素缺乏的风险增加 2.11 倍:结论:在系统性红斑狼疮患者和 HS 中,降钙素缺乏、维生素 D 膳食摄入不足以及不坚持摄入富含维生素 D 的食物来源的模式与高心脏代谢风险有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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