Evaluating the Risk of Malignancies of the Diagnostic Categories Proposed by the World Health Organization System for Reporting Lung Cytopathology: A 2-Year Single Institutional Experience.

IF 1.6 4区医学 Q3 PATHOLOGY

Acta Cytologica Pub Date : 2024-01-01 Epub Date: 2024-05-02 DOI:10.1159/000539154

Wei-An Lai, Chien-Chin Chen

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引用次数: 0

Abstract

Introduction: The WHO System of Reporting Lung Cytopathology proposed a 5-tiered system in 2023. We report the risk of malignancies (ROMs) of bronchial washing/lavage and percutaneous fine-needle aspiration (FNA) specimens. We also evaluated the change of ROMs when image correlation is required.

Methods: Lung cytology cases in 2021 and 2022 with histologic follow-up were included. CT reports were reviewed to identify cases with a solid nodule/tumor but benign cytological findings. These were reassigned from the "benign" to "non-diagnostic" category, and the ROMs were re-estimated.

Results: A total of 1,031 bronchial washing/lavage and 206 FNAs were identified. The ROMs of bronchial washing/lavage were "non-diagnostic" 56.5% (13/23), "benign" 41.9% (320/764), "atypical" 71.7% (71/99), "suspicious for malignancy" 94.7% (72/76), and "malignant" 100% (70/70). The ROMs of FNAs were "non-diagnostic" 66% (33/50), "benign" 58.2% (39/67), "atypical" 70% (28/40), "suspicious for malignancy" 96.2% (25/26), and "malignant" 100% (70/70). When image finding was considered, cases initially assigned as "benign" were re-classified to "non-diagnostic" with decreases in ROMs for the "benign" category.

Conclusions: Malignancy risks associated with the WHO System of Reporting Lung Cytopathology diagnostic groups were reported. Image correlation for the "benign" category led to a decrease in case number and ROM.

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评估世界卫生组织肺细胞病理学报告系统提出的诊断类别的恶性肿瘤风险：两年的单一机构经验。

引言世界卫生组织肺细胞病理学报告系统于 2023 年提出了一个 5 级系统。我们报告了支气管冲洗/淋巴液和经皮细针穿刺（FNA）标本的恶性肿瘤风险（ROMs）。我们还评估了需要图像相关性时 ROMs 的变化。方法纳入 2021 年和 2022 年组织学随访的肺细胞学病例。对 CT 报告进行审查，以确定有实性结节/肿瘤但细胞学结果为良性的病例。将这些病例从 "良性 "类别重新归类为 "非诊断性 "类别，并重新估算 ROM。结果共鉴定出 1031 例支气管冲洗/淋巴结肿块和 206 例 FNA。支气管冲洗/黏膜检查的 ROM 为 "非诊断 "56.5%（13/23）、"良性 "41.9%（320/764）、"非典型 "71.7%（71/99）、"可疑恶性 "94.7%（72/76）和 "恶性 "100%（70/70）。FNA 的 ROM 分别为 "非诊断性 "66%（33/50）、"良性 "58.2%（39/67）、"非典型 "70%（28/40）、"可疑恶性 "96.2%（25/26）和 "恶性 "100%（70/70）。在考虑图像发现时，最初被归类为 "良性 "的病例被重新归类为 "非诊断性"，"良性 "类别的 ROMs 有所下降。结论报告了与世界卫生组织肺细胞病理学报告系统诊断组别相关的恶性肿瘤风险。良性 "类别的图像相关性导致病例数和ROM下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Cytologica 生物-病理学

CiteScore

3.70

自引率

11.10%

发文量

审稿时长

4-8 weeks

期刊介绍： With articles offering an excellent balance between clinical cytology and cytopathology, ''Acta Cytologica'' fosters the understanding of the pathogenetic mechanisms behind cytomorphology and thus facilitates the translation of frontline research into clinical practice. As the official journal of the International Academy of Cytology and affiliated to over 50 national cytology societies around the world, ''Acta Cytologica'' evaluates new and existing diagnostic applications of scientific advances as well as their clinical correlations. Original papers, review articles, meta-analyses, novel insights from clinical practice, and letters to the editor cover topics from diagnostic cytopathology, gynecologic and non-gynecologic cytopathology to fine needle aspiration, molecular techniques and their diagnostic applications. As the perfect reference for practical use, ''Acta Cytologica'' addresses a multidisciplinary audience practicing clinical cytopathology, cell biology, oncology, interventional radiology, otorhinolaryngology, gastroenterology, urology, pulmonology and preventive medicine.