Clinical, Morphological and Molecular Features of Spitz tumors.

Q4 Medicine
Ceskoslovenska patologie Pub Date : 2024-01-01
Michele Donati, Boulos Mansour, Michael Hagstrom, Pedram Gerami, Dmitry V Kazakov
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引用次数: 0

Abstract

Spitz tumors represent a heterogeneous group of challenging melanocytic neoplasms, displaying a range of biological behaviors, spanning from benign lesions, Spitz nevi (SN) to Spitz melanomas (SM), with intermediate lesions in between known as atypical Spitz tumors (AST). They are histologically characterized by large epithelioid and/or spindled melanocytes arranged in fascicles or nests, often associated with characteristic epidermal hyperplasia and fibrovascular stromal changes. In the last decade, the detection of mutually exclusive structural rearrangements involving receptor tyrosine kinases ROS1, ALK, NTRK1, NTRK2, NTRK3, RET, MET, serine threonine kinases BRAF and MAP3K8, or HRAS mutation, led to a clinical, morphological and molecular based classification of Spitz tumors. The recognition of some reproducible histological features can help dermatopathologist in assessing these lesions and can provide clues to predict the underlying molecular driver. In this review, we will focus on clinical and morphological findings in molecular Spitz tumor subgroups.

斯皮茨肿瘤的临床、形态和分子特征。
斯皮茨瘤是一组具有挑战性的黑素细胞瘤,表现出一系列生物学行为,包括从良性病变斯皮茨痣(SN)到斯皮茨黑素瘤(SM),以及介于两者之间的被称为非典型斯皮茨瘤(AST)的中间病变。它们的组织学特征是大的上皮样和/或纺锤形黑素细胞呈束状或巢状排列,通常伴有特征性的表皮增生和纤维血管基质改变。在过去的十年中,由于发现了涉及受体酪氨酸激酶 ROS1、ALK、NTRK1、NTRK2、NTRK3、RET、MET、丝氨酸苏氨酸激酶 BRAF 和 MAP3K8 或 HRAS 突变的相互排斥的结构重排,从而对 Spitz 肿瘤进行了基于临床、形态学和分子学的分类。对一些可重复的组织学特征的认识有助于皮肤病理学家评估这些病变,并为预测潜在的分子驱动因素提供线索。在本综述中,我们将重点讨论分子Spitz肿瘤亚组的临床和形态学发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Ceskoslovenska patologie
Ceskoslovenska patologie Medicine-Medicine (all)
CiteScore
0.40
自引率
0.00%
发文量
17
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