Effectiveness of the Therapeutic Lifestyle Change Diet Intervention to Improve Biochemical Markers of Cardiovascular Diseases in HIV-Infected Patients with Dyslipidemia.

IF 3.2 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Annals of Nutrition and Metabolism Pub Date : 2024-01-01 Epub Date: 2024-04-22 DOI:10.1159/000538578

Alongkote Singhato, Uraiporn Booranasuksakul, Somjet Khongkhon, Narisa Rueangsri

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引用次数: 0

Abstract

Introduction: This randomized controlled trial study aimed to investigate the effectiveness of therapeutic lifestyle change (TLC) diet intervention by the registered dietitians.

Methods: Eighty-two people living with HIV (PLHIV) with dyslipidemia were randomly allocated to the intervention group as well as another 82 PLHIV with dyslipidemia to the control group. Participants in the intervention group were instructed to meet the registered dietitians every 2 weeks at weeks 0, 2, 4, 6, and 12 (a totally of 12 weeks) to receive individual medical nutrition therapy according to the TLC diet principles, while the participants in the control group only received routine health care service.

Results: Triglycerides, total cholesterol, and LDL cholesterol of the intervention group were significantly lower than those of the control group at the endpoint (p < 0.05). In addition, these biomarkers and C-reactive protein of the intervention group were significantly lower when compared with their baseline (p < 0.05). The overall dietary habits of participants in the intervention group were significantly improved at the end of the study (p < 0.05).

Conclusion: The medical nutrition therapy intervention based on the TLC diet is effective in improving blood lipid profiles among PLHIV with dyslipidemia.

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治疗性改变生活方式饮食干预对改善患有血脂异常的艾滋病病毒感染者心血管疾病生化指标的效果。

目的方法：将 82 名患有血脂异常的艾滋病病毒感染者（PLHIV）随机分配到干预组，同时将另外 82 名患有血脂异常的艾滋病病毒感染者随机分配到对照组。干预组的参与者在第 0、2、4、6 和 12 周（共 12 周）每两周接受一次注册营养师的指导，根据 TLC 饮食原则接受个人医学营养治疗，而对照组的参与者只接受常规的医疗保健服务：结果：干预组的甘油三酯、总胆固醇和低密度脂蛋白胆固醇在终点时明显低于对照组（p 结论：基于TLC饮食原则的医学营养疗法干预效果显著：以TLC饮食为基础的医学营养治疗干预能有效改善血脂异常艾滋病毒感染者的血脂状况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Nutrition and Metabolism 医学-内分泌学与代谢

CiteScore

6.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Annals of Nutrition and Metabolism'' is a leading international peer-reviewed journal for sharing information on human nutrition, metabolism and related fields, covering the broad and multidisciplinary nature of science in nutrition and metabolism. As the official journal of both the International Union of Nutritional Sciences (IUNS) and the Federation of European Nutrition Societies (FENS), the journal has a high visibility among both researchers and users of research outputs, including policy makers, across Europe and around the world.