Glycyrrhizin functionalized CuS Nanoprobes for NIR Light-based therapeutic mitigation of acne vulgaris.

IF 5.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Drug Delivery and Translational Research Pub Date : 2024-10-01 Epub Date: 2024-05-04 DOI:10.1007/s13346-024-01594-x

Srivathsan Ganeshan, Nidhi Parihar, Donker Chonzom, Dinesh Mohanakrishnan, Rajdeep Das, Dandadhar Sarma, Devipriya Gogoi, Manash Ranjan Das, Suryanarayana Murty Upadhayula, Deepak Bharadwaj Pemmaraju

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Abstract

Acne Vulgaris or Acne is a multifactorial bacterial infection caused by Propionibacterium acne, leading to inflammation and decreased quality of life, especially in adolescence. Currently, antibiotics and retinoids are preferred for treating acne. However, their continuous usage may lead to anti-microbial resistance and other side effects. Therefore, research on developing effective strategies to reduce antimicrobial resistance and improve acne healing is ongoing. The current work reports the synthesis and evaluation of near-infrared light-absorbing copper sulfide (CuS) nanoparticles loaded with a biomolecule, Glycyrrhizin (Ga). The photothermal efficacy studies, and in-vitro and in-vivo experiments indicated that the Ga-CuS NPs generated localized hyperthermia in acne-causing bacteria, leading to their complete growth inhibition. The results indicated that the Ga-Cus NPs possess excellent antibacterial and anti-inflammatory properties in the acne and inflammatory models. This could be from the synergistic effect of CuS NPs mediated mild Photothermal effect and inherent pharmacological properties of Ga. Further detailed studies of the formulations can pave the way for application in cosmetic clinics for the effective and minimally invasive management of Acne-like conditions.

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甘草酸苷功能化 CuS 纳米探针用于基于近红外光的痤疮治疗缓解。

粉刺或痤疮是由痤疮丙酸杆菌引起的一种多因素细菌感染，导致炎症和生活质量下降，尤其是在青春期。目前，抗生素和维甲酸是治疗痤疮的首选药物。然而，持续使用这些药物可能会导致抗微生物抗药性和其他副作用。因此，减少抗菌药耐药性和改善痤疮愈合的有效策略研究仍在进行中。目前的工作报告了载入生物大分子甘草苷（Ga）的近红外光吸收硫化铜（CuS）纳米粒子的合成和评估。光热效应研究以及体外和体内实验表明，Ga-CuS NPs 能对痤疮丙酸杆菌产生局部热效应，从而完全抑制其生长。结果表明，在痤疮和炎症模型中，Ga-CuS NPs 具有优异的抗菌和消炎特性。这可能是由于 CuS NPs 介导的温和光热效应和 Ga 固有的药理特性所产生的协同效应。对这些制剂的进一步详细研究可为其在美容诊所的应用铺平道路，从而对痤疮类病症进行有效的微创治疗。

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来源期刊

Drug Delivery and Translational Research MEDICINE, RESEARCH & EXPERIMENTALPHARMACOL-PHARMACOLOGY & PHARMACY

CiteScore

11.70

自引率

1.90%

发文量

160

期刊介绍： The journal provides a unique forum for scientific publication of high-quality research that is exclusively focused on translational aspects of drug delivery. Rationally developed, effective delivery systems can potentially affect clinical outcome in different disease conditions. Research focused on the following areas of translational drug delivery research will be considered for publication in the journal. Designing and developing novel drug delivery systems, with a focus on their application to disease conditions; Preclinical and clinical data related to drug delivery systems; Drug distribution, pharmacokinetics, clearance, with drug delivery systems as compared to traditional dosing to demonstrate beneficial outcomes Short-term and long-term biocompatibility of drug delivery systems, host response; Biomaterials with growth factors for stem-cell differentiation in regenerative medicine and tissue engineering; Image-guided drug therapy, Nanomedicine; Devices for drug delivery and drug/device combination products. In addition to original full-length papers, communications, and reviews, the journal includes editorials, reports of future meetings, research highlights, and announcements pertaining to the activities of the Controlled Release Society.