A case report of Capnocytophaga canimorsus meningitis with failure of ceftriaxone therapy.

Q3 Medicine

JAMMI Pub Date : 2024-03-29 eCollection Date: 2024-03-01 DOI:10.3138/jammi-2023-0003

Emily C Wildman, Nicole Brockman, Bonnie L Meatherall

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Abstract

Background: Capnocytophaga canimorsus is a gram-negative zoonotic organism that has the potential to cause devastating human infection. Historically, treatment with beta-lactams including penicillin and ceftriaxone has been effective.

Methods: We describe a complicated case of C. canimorsus meningitis in a 70-year-old female following a superficial puncture wound from her dog's teeth.

Results: The case described here was complicated by seizures following treatment with ceftriaxone therapy. This case is also the first reported case of C. canimorsus meningitis associated with moyamoya disease and fibromuscular dysplasia.

Conclusions: Physicians should be aware of the possibility of ceftriaxone-resistant C. canimorsus and have a low threshold to broaden antimicrobial coverage in the absence of clinical improvement. We also raise the possibility of an association between vasculopathies and unusual infections like C. canimorsus.

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一例头孢曲松治疗失败的卡氏嗜血杆菌脑膜炎病例报告。

背景：卡氏嗜血杆菌（Capnocytophaga canimorsus）是一种革兰氏阴性人畜共患病，有可能对人类造成毁灭性感染。一直以来，使用包括青霉素和头孢曲松在内的β-内酰胺类药物治疗效果显著：方法：我们描述了一名 70 岁女性被狗牙刺伤后并发卡尼莫氏菌脑膜炎的病例：结果：该病例在接受头孢曲松治疗后并发了癫痫。本病例也是首例报道的卡尼莫氏菌脑膜炎伴有莫亚莫亚病和纤维肌发育不良的病例：结论：医生应意识到头孢曲松耐药卡尼莫司菌的可能性，在临床症状没有改善的情况下，扩大抗菌药物覆盖范围的门槛要低。我们还提出了血管病变与卡尼莫司菌等异常感染之间存在关联的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JAMMI Medicine-Infectious Diseases

CiteScore

3.80

自引率

0.00%

发文量