Prognostic value and immunological function of cuproptosis-related genes in lung adenocarcinoma.

IF 3.4 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Heliyon Pub Date : 2024-04-27 eCollection Date: 2024-05-15 DOI:10.1016/j.heliyon.2024.e30446

Liming Zhang, Shaoqiang Wang, Lina Wang

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引用次数: 0

Abstract

Background: Lung cancer is one of the malignant tumors with the highest morbidity and fatality rates worldwide. The overall survival (OS) of lung adenocarcinoma (LUAD) is poor. Cuproptosis is a copper-triggered modality of mitochondrial cell death, however, its contribution to the emergence of lung cancer is unknown. The clinical implication and immunological function of cuproptosis-related genes (CRGs) in LUAD has yet to be established.

Methods: TCGA, HPA, GEPIA, Kaplan-Meier, TIMER and CancerSEA database were used to explore the prognostic value and biological function of CRGs in LUAD.

Results: CRGs are primarily involved in copper ion transport, the citrate cycle (TCA cycle) and central carbon metabolism in LUAD. The mRNA expression of COA6, UBE2D1, DLAT, SLC25A3, and DBH was significantly increased. The expression of COA6, DLAT, SLC25A3, DBH, and LOXL2 were all strongly associated with the clinicopathological stages in LUAD. Moreover, high expression of COA6, UBE2D1, DLAT, SLC25A3 and LOXL2 was related to poor OS. The expression of SLC25A3 and LOXL2 showed different association with immune cell infiltration. The single cell sequencing demonstrated that CRGs play important roles in the regulation of DNA damage response, inflammation and metastasis in LUAD.

Conclusions: In summary, this study comprehensively uncovered that CRGs could be identified as potential prognostic and immunological biomarkers in LUAD. Our current research could provide a solid theoretical basis for LUAD survival research and clinical decision-making.

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肺腺癌杯突相关基因的预后价值和免疫功能

背景：肺癌是全球发病率和死亡率最高的恶性肿瘤之一：肺癌是全世界发病率和死亡率最高的恶性肿瘤之一。肺腺癌（LUAD）的总生存率（OS）很低。铜中毒是一种铜触发的线粒体细胞死亡模式，但它对肺癌发生的贡献尚不清楚。铜突相关基因（CRGs）在肺癌中的临床意义和免疫学功能尚未确定：方法：利用TCGA、HPA、GEPIA、Kaplan-Meier、TIMER和CancerSEA数据库探讨CRGs在LUAD中的预后价值和生物学功能：结果：CRGs在LUAD中主要参与铜离子转运、柠檬酸循环（TCA循环）和中心碳代谢。COA6、UBE2D1、DLAT、SLC25A3和DBH的mRNA表达明显增加。COA6、DLAT、SLC25A3、DBH和LOXL2的表达均与LUAD的临床病理分期密切相关。此外，COA6、UBE2D1、DLAT、SLC25A3和LOXL2的高表达与不良OS有关。SLC25A3和LOXL2的表达与免疫细胞浸润有不同的关系。单细胞测序结果表明，CRGs在LUAD的DNA损伤反应、炎症和转移调控中发挥着重要作用：综上所述，本研究全面揭示了CRGs可作为LUAD潜在的预后和免疫学生物标志物。我们目前的研究可为 LUAD 的生存研究和临床决策提供坚实的理论基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heliyon MULTIDISCIPLINARY SCIENCES-

CiteScore

4.50

自引率

2.50%

发文量

2793

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