The Effects of FABP4 on Cardiovascular Disease in the Aging Population.

IF 5.7 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Current Atherosclerosis Reports Pub Date : 2024-05-01 Epub Date: 2024-05-03 DOI:10.1007/s11883-024-01196-5

Ellen M van der Ark-Vonk, Mike V Puijk, Gerard Pasterkamp, Sander W van der Laan

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Abstract

Purpose of review: Fatty acid-binding protein 4 (FABP4) plays a role in lipid metabolism and cardiovascular health. In this paper, we cover FABP4 biology, its implications in atherosclerosis from observational studies, genetic factors affecting FABP4 serum levels, and ongoing drug development to target FABP4 and offer insights into future FABP4 research.

Recent findings: FABP4 impacts cells through JAK2/STAT2 and c-kit pathways, increasing inflammatory and adhesion-related proteins. In addition, FABP4 induces angiogenesis and vascular smooth muscle cell proliferation and migration. FABP4 is established as a reliable predictive biomarker for cardiovascular disease in specific at-risk groups. Genetic studies robustly link PPARG and FABP4 variants to FABP4 serum levels. Considering the potential effects on atherosclerotic lesion development, drug discovery programs have been initiated in search for potent inhibitors of FABP4. Elevated FABP4 levels indicate an increased cardiovascular risk and is causally related to acceleration of atherosclerotic disease, However, clinical trials for FABP4 inhibition are lacking, possibly due to concerns about available compounds' side effects. Further research on FABP4 genetics and its putative causal role in cardiovascular disease is needed, particularly in aging subgroups.

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FABP4 对老龄人口心血管疾病的影响

综述的目的：脂肪酸结合蛋白 4 (FABP4) 在脂质代谢和心血管健康中发挥作用。在本文中，我们将介绍 FABP4 的生物学特性、观察性研究对动脉粥样硬化的影响、影响 FABP4 血清水平的遗传因素以及正在进行的针对 FABP4 的药物开发，并对未来的 FABP4 研究提出见解：FABP4通过JAK2/STAT2和c-kit通路影响细胞，增加炎症和粘附相关蛋白。此外，FABP4 还能诱导血管生成、血管平滑肌细胞增殖和迁移。FABP4 已被确定为特定高危人群心血管疾病的可靠预测生物标志物。遗传研究将 PPARG 和 FABP4 变异与 FABP4 血清水平紧密联系在一起。考虑到 FABP4 对动脉粥样硬化病变发展的潜在影响，已经启动了药物发现计划，寻找 FABP4 的强效抑制剂。FABP4 水平升高表明心血管风险增加，并与动脉粥样硬化疾病的加速发展有因果关系，但可能由于对现有化合物副作用的担忧，目前还缺乏对 FABP4 抑制剂的临床试验。我们需要进一步研究 FABP4 遗传学及其在心血管疾病中的可能因果作用，特别是在老龄亚群体中。

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来源期刊

Current Atherosclerosis Reports 医学-

CiteScore

9.00

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of this journal is to systematically provide expert views on current basic science and clinical advances in the field of atherosclerosis and highlight the most important developments likely to transform the field of cardiovascular prevention, diagnosis, and treatment. We accomplish this aim by appointing major authorities to serve as Section Editors who select leading experts from around the world to provide definitive reviews on key topics and papers published in the past year. We also provide supplementary reviews and commentaries from well-known figures in the field. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.