Investigating Majhool date (Phoenix dactylifera) consumption effects on fasting blood glucose in animals and humans.

Q3 Pharmacology, Toxicology and Pharmaceutics
Yazun Jarrar, Ruba Balasmeh, Wisam Naser, Rami Mosleh, Amin A Al-Doaiss, Mohammed Ali AlShehri
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引用次数: 0

Abstract

Objectives: Majhool date (Phoenix dactylifera), renowned for its premium taste and texture, is extensively consumed in the Islamic world, particularly during Ramadan. Despite its popularity, concerns persist regarding its potential to induce diabetes in non-patients. This study aims to explore the diabetogenic effects of prolonged Majhool date (Phoenix dactylifera) consumption, the widely used fruit in the Islamic world, through animal experiments and human clinical data.

Methods: Medjool dates were processed into an ethanolic extract for the animal experiment. Then, 21 Balb/c mice received varying doses of the extract for one month. The fasting blood glucose levels were analyzed at the beginning and after one month of consumption of the Majhool date extract. For the clinical study, 387 healthy participants were recruited, with fasting blood glucose levels assessed before and after Ramadan, a period of heightened Majhool date consumption.

Results: all groups of the experimental animals exhibited a significant (p<0.05) weight increase after Majhool date consumption, while no significant (p>0.05) alteration in fasting blood glucose levels among groups. In addition, it was found that fasting blood glucose levels remained statistically unchanged (p>0.05) after heightened Majhool date consumption among humans.

Conclusions: The study challenges the belief that Majhool date induces diabetes, supported by both animal and human data. Findings suggest that Majhool date consumption, even at higher doses, does not induce diabetes. Further investigations could explore the impact of other date varieties on the fasting blood glucose levels.

研究食用马枣(Phoenix dactylifera)对动物和人类空腹血糖的影响。
目的:马月枣(Phoenix dactylifera)以其优质的口感和质地而闻名,在伊斯兰世界被广泛食用,尤其是在斋月期间。尽管它很受欢迎,但人们仍然担心它可能会诱发非患者的糖尿病。本研究旨在通过动物实验和人体临床数据,探讨伊斯兰世界广泛使用的水果,即长期食用麦卓枣(Phoenix dactylifera)对糖尿病的影响:方法:在动物实验中,将麦枣加工成乙醇提取物。然后,21 只 Balb/c 小鼠在一个月内接受了不同剂量的提取物。在开始服用和服用一个月后,对空腹血糖水平进行了分析。在临床研究中,招募了 387 名健康参与者,在斋月前后评估空腹血糖水平,斋月是食用马月枣较多的时期。此外,研究还发现,人类在大量食用马月枣后,空腹血糖水平在统计学上保持不变(p>0.05):结论:这项研究对 "马家胡枣会诱发糖尿病 "的观点提出了质疑,动物和人体数据都支持这一观点。研究结果表明,即使食用较高剂量的马月枣,也不会诱发糖尿病。进一步的研究可以探讨其他枣类对空腹血糖水平的影响。
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来源期刊
Journal of Basic and Clinical Physiology and Pharmacology
Journal of Basic and Clinical Physiology and Pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
3.90
自引率
0.00%
发文量
53
期刊介绍: The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and phytotherapy. As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes. Topics: Behavior and Neuroprotection, Reproduction, Genotoxicity and Cytotoxicity, Vascular Conditions, Cardiovascular Function, Cardiovascular-Pulmonary Interactions, Oxidative Stress, Metabolism, Immune Response, Hematological Profile, Inflammation, Infection, Phytotherapy.
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