Decapping NAD-RNAs: TIR domain-containing proteins stand out for specificity

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2024-06-01 DOI:10.1016/j.tibs.2024.04.004

Dechang Cao

引用次数: 0

Abstract

A recently characterized RNA modification is NAD⁺-modified RNAs (NAD-RNAs). Various enzymes decap NAD-RNAs, and Wang and Yu et al. now describe another, namely Toll/interleukin-1 receptor (TIR) domain-containing proteins of bacteria and Archaea. TIR decapping products are a specific variant of cyclic ADP ribose (ADPR)-RNAs (v-cADPR-RNAs), opening a new window to the NAD-RNA world.

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为 NAD-RNA 解旋：含 TIR 结构域的蛋白质具有突出的特异性。

最近发现的一种 RNA 修饰是 NAD+ 修饰 RNA（NAD-RNA）。现在，Wang 和 Yu 等人描述了另一种酶，即细菌和古细菌的含 Toll/interleukin-1 受体（TIR）结构域的蛋白。TIR 脱帽产物是环状 ADP 核糖（ADPR）-RNA（v-cADPR-RNA）的一种特殊变体，为 NAD-RNA 世界打开了一扇新窗口。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

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