Assessing PET/CT's diagnostic accuracy in idiopathic myopathies.

IF 0.9 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Hellenic journal of nuclear medicine Pub Date : 2024-01-01 DOI:10.1967/s002449912711

Feng Liang, Guanxi Li, Junhong Guo, Wei Zhang, Xueli Chang

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引用次数: 0

Abstract

Objective: Recent studies have utilized fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) specifically to diagnose cases of idiopathic inflammatory myopathies (IIM), excluding inclusion body myositis (IBM). Conversely, carbon-11 (¹¹C) labeled Pittsburgh compound B (PIB)-PET imaging is exclusively used for the detection of IBM. This research is designed to evaluate the diagnostic accuracy of PET/CT in identifying IIM by employing rigorous diagnostic accuracy testing methodologies.

Materials and methods: A systematic review and meta-analysis were conducted across multiple databases including PubMed, and Embase. We focused on the diagnostic utility of PET/CT in IIM, assessing sensitivities, specificities, and deriving likelihood ratios (LR+ and LR-). The study was registered with PROSPERO (CRD42022343222).

Results: This systematic review identified 635 citations, of which 10 eligible trials were included, with a total of 419 participants. The results indicated a sensitivity of 0.86 (0.81-0.90), and a specificity of 0.93 (0.88-0.96). The synthesis of LR revealed the LR+ of 10.35 (6.31-16.98), and LR-of 0.15 (0.07-0.32). The summary receiver operating characteristic curve (SROC) showed an area under the curve (AUC) of 0.9658. Regarding IBM, the sensitivity was 0.84 (0.60-0.97), and the specificity was 1 (0.69-1). The synthesis of LR showed the LR+ of 9.61 (1.46-63.15) and an LR- of 0.21 (0.09-0.51). For disease activity, the sensitivity was 0.96 (0.92-0.99), and the specificity was 0.91 (0.084-0.96). The synthesis of LR showed an LR+ of 9.43 (5.39-16.51) and an LR- of 0.05 (0.02-0.11).

Conclusion: Positron emission tomography/CT has great potential for accurately diagnosing and monitoring patients with IIM, and may have implications for their clinical management.

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评估 PET/CT 对特发性肌病的诊断准确性。

目的：最近的研究利用氟-18-氟脱氧葡萄糖（18F-FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）专门诊断特发性炎症性肌病（IIM）病例，但不包括包涵体肌炎（IBM）。相反，碳-11（11C）标记的匹兹堡化合物 B（PIB）-PET 成像则专门用于检测 IBM。本研究旨在通过采用严格的诊断准确性测试方法，评估 PET/CT 在鉴别 IBM 方面的诊断准确性：我们在多个数据库（包括 PubMed 和 Embase）中进行了系统回顾和荟萃分析。我们重点研究了 PET/CT 对 IIM 的诊断效用，评估了敏感性、特异性并得出了似然比（LR+ 和 LR-）。该研究已在 PROSPERO（CRD42022343222）注册：本系统综述共发现 635 条引文，其中纳入了 10 项符合条件的试验，共有 419 名参与者。结果显示，灵敏度为 0.86（0.81-0.90），特异性为 0.93（0.88-0.96）。LR 综合显示，LR+ 为 10.35（6.31-16.98），LR 为 0.15（0.07-0.32）。接受者操作特征曲线（SROC）的曲线下面积（AUC）为 0.9658。IBM 的灵敏度为 0.84（0.60-0.97），特异性为 1（0.69-1）。LR 综合显示，LR+ 为 9.61（1.46-63.15），LR- 为 0.21（0.09-0.51）。疾病活动性的敏感性为 0.96（0.92-0.99），特异性为 0.91（0.084-0.96）。LR 综合显示，LR+ 为 9.43（5.39-16.51），LR- 为 0.05（0.02-0.11）：正电子发射断层扫描/CT 在准确诊断和监测 IIM 患者方面具有巨大潜力，并可能对患者的临床治疗产生影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hellenic journal of nuclear medicine 医学-核医学

CiteScore

1.40

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： The Hellenic Journal of Nuclear Medicine published by the Hellenic Society of Nuclear Medicine in Thessaloniki, aims to contribute to research, to education and cover the scientific and professional interests of physicians, in the field of nuclear medicine and in medicine in general. The journal may publish papers of nuclear medicine and also papers that refer to related subjects as dosimetry, computer science, targeting of gene expression, radioimmunoassay, radiation protection, biology, cell trafficking, related historical brief reviews and other related subjects. Original papers are preferred. The journal may after special agreement publish supplements covering important subjects, dully reviewed and subscripted separately.