A Step Test to Evaluate the Susceptibility to Severe High-Altitude Illness in Field Conditions.

IF 1.6 4区 医学 Q4 BIOPHYSICS
High altitude medicine & biology Pub Date : 2024-09-01 Epub Date: 2024-04-29 DOI:10.1089/ham.2023.0065
Eric Hermand, Léo Lesaint, Laura Denis, Jean-Paul Richalet, François J Lhuissier
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Abstract

Hermand, Eric, Léo Lesaint, Laura Denis, Jean-Paul Richalet, and François J. Lhuissier. A step test to evaluate the susceptibility to severe high-altitude illness in field conditions. High Alt Med Biol. 25:158-163, 2024.-A laboratory-based hypoxic exercise test, performed on a cycle ergometer, can be used to predict susceptibility to severe high-altitude illness (SHAI) through the calculation of a clinicophysiological SHAI score. Our objective was to design a field-condition test and compare its derived SHAI score and various physiological parameters, such as peripheral oxygen saturation (SpO2), and cardiac and ventilatory responses to hypoxia during exercise (HCRe and HVRe, respectively), to the laboratory test. A group of 43 healthy subjects (15 females and 28 males), with no prior experience at high altitude, performed a hypoxic cycle ergometer test (simulated altitude of 4,800 m) and step tests (20 cm high step) at 3,000, 4,000, and 4,800 m simulated altitudes. According to tested altitudes, differences were observed in O2 desaturation, heart rate, and minute ventilation (p < 0.001), whereas the computed HCRe and HVRe were not different (p = 0.075 and p = 0.203, respectively). From the linear relationships between the step test and SHAI scores, we defined a risk zone, allowing us to evaluate the risk of developing SHAI and take adequate preventive measures in field conditions, from the calculated step test score for the given altitude. The predictive value of this new field test remains to be validated in real high-altitude conditions.

在野外条件下评估严重高海拔疾病易感性的步骤测试。
埃里克-赫尔曼、莱奥-莱桑特、劳拉-丹尼斯、让-保罗-里夏尔和弗朗索瓦-J.-吕西埃。在野外条件下评估严重高海拔疾病易感性的步骤测试。00:000-000, 2024.-在自行车测力计上进行的实验室缺氧运动测试可通过计算临床生理学 SHAI 分数来预测对严重高海拔疾病(SHAI)的易感性。我们的目的是设计一种现场条件测试,并将其得出的 SHAI 分数和各种生理参数(如外周血氧饱和度(SpO2)、运动时心脏和呼吸对缺氧的反应(分别为 HCRe 和 HVRe))与实验室测试进行比较。一组 43 名没有高海拔经验的健康受试者(15 名女性和 28 名男性)在模拟海拔 3,000 米、4,000 米和 4,800 米处进行了缺氧循环测力计测试(模拟海拔 4,800 米)和台阶测试(20 厘米高台阶)。根据测试的海拔高度,观察到氧气饱和度、心率和分钟通气量存在差异(p < 0.001),而计算的 HCRe 和 HVRe 没有差异(分别为 p = 0.075 和 p = 0.203)。根据台阶试验和 SHAI 分数之间的线性关系,我们定义了一个风险区,使我们能够根据计算出的给定海拔高度的台阶试验分数,评估罹患 SHAI 的风险,并在野外条件下采取适当的预防措施。这种新的野外测试的预测价值还有待在真实的高海拔条件下进行验证。
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来源期刊
High altitude medicine & biology
High altitude medicine & biology 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.80
自引率
9.50%
发文量
44
审稿时长
>12 weeks
期刊介绍: High Altitude Medicine & Biology is the only peer-reviewed journal covering the medical and biological issues that impact human life at high altitudes. The Journal delivers critical findings on the impact of high altitude on lung and heart disease, appetite and weight loss, pulmonary and cerebral edema, hypertension, dehydration, infertility, and other diseases. It covers the full spectrum of high altitude life sciences from pathology to human and animal ecology.
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