Estimated glomerular filtration rate in clinical practice: Consensus positioning of the Brazilian Society of Nephrology (SBN) and Brazilian Society of Clinical Pathology and Laboratory Medicine (SBPC/ML).
Gianna Mastroianni Kirsztajn, Geraldo Bezerra da Silva Junior, Artur Quintiliano Bezerra da Silva, Hugo Abensur, João Egídio Romão Junior, Marcus Gomes Bastos, Viviane Calice-Silva, Lilian Pires de Freitas do Carmo, Tainá Veras de Sandes-Freitas, Patrícia Ferreira Abreu, Bruna Dolci Andreguetto, Luiz Gustavo Ferreira Cortes, Maria Gabriela de Lucca Oliveira, Luisane Maria Falci Vieira, José A Moura-Neto, Adagmar Andriolo
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Abstract
Chronic kidney disease (CKD) represents one of today's main public health problems. Serum creatinine measurement and estimation of the glomerular filtration rate (GFR) are the main tools for evaluating renal function. There are several equations to estimate GFR, and CKD-EPI equation (Chronic Kidney Disease - Epidemiology) is the most recommended one. There are still some controversies regarding serum creatinine measurement and GFR estimation, since several factors can interfere in this process. An important recent change was the removal of the correction for race from the equations for estimating GFR, which overestimated kidney function, and consequently delayed the implementation of treatments such as dialysis and kidney transplantation. In this consensus document from the Brazilian Societies of Nephrology and Clinical Pathology and Laboratory Medicine, the main concepts related to the assessment of renal function are reviewed, as well as possible existing controversies and recommendations for estimating GFR in clinical practice.
慢性肾病（CKD）是当今主要的公共卫生问题之一。血清肌酐测量和肾小球滤过率（GFR）估算是评估肾功能的主要工具。有几种估算 GFR 的方程，而 CKD-EPI 方程（慢性肾脏病-流行病学）是最值得推荐的一种。在血清肌酐测量和 GFR 估算方面仍存在一些争议，因为有几个因素会干扰这一过程。最近的一个重要变化是在估算 GFR 的公式中取消了种族校正，因为种族校正会高估肾功能，从而延误透析和肾移植等治疗的实施。在这份由巴西肾脏病学会和临床病理学与实验室医学学会共同编写的共识文件中，回顾了与肾功能评估相关的主要概念，以及在临床实践中估算 GFR 时可能存在的争议和建议。
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