Decision Coaching for Healthy Women With BRCA1/2 Pathogenic Variants.

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2024-06-14 DOI:10.3238/arztebl.m2024.0049

Stephanie Stock, Anna Isselhard, Arim Shukri, Sibylle Kautz-Freimuth, Marcus Redaèlli, Birte Berger-Höger, Nicola Dikow, Marion Kiechle, Juliane Köberlein-Neu, Cornelia Meisel, Rita Schmutzler, Anke Steckelberg, Marion Tina van Mackelenbergh, Frank Vitinius, Achim Wöckel, Kerstin Rhiem

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引用次数: 0

Abstract

Background: Women with pathogenic variants (PV) of the genes BRCA1/2 have a choice of preventive options. To help these women decide for themselves, we developed and implemented a decision coaching (DC) program and evaluated it for congruence between the participants' desired and actual roles in decision-making.

Methods: Healthy BRCA1/2 PV carriers (25-60 years of age) were recruited at six centers in Germany. Those who returned baseline (T1) questionnaires were randomly assigned to the intervention group (IG) or the control group (CG). The IG attended a nurse-led DC program. The primary outcome was congruence between the participants' preferred and actual roles in decision-making. The secondary outcomes were an active role, satisfaction, decisional conflict, and knowledge. The follow-up questionnaires were administered at 12 weeks (T2) and 6 months (T3).

Results: Of the 413 women who were recruited, 389 returned the T1 questionnaires. At T2, the groups did not differ significantly in congruence between their preferred and actual roles in decision-making (0.12, 95% confidence interval [-0.03; 0.28], p = 0.128), with a slightly higher congruence in the CG. Women in both groups played a more active role at T2 than their stated preference at T1, with a notably higher percentage in the IG than the CG (IG: 40%, CG: 24.4% [-25.1; -6.1]). IG participants were more satisfied with their role and had less decisional conflict and greater knowledge.

Conclusion: This DC program can help women who are carriers of BRCA1/2 PV participate actively in decision-making with regard to preventive measures.

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对患有 BRCA1/2 致病变异的健康女性进行决策辅导--EDCP-BRCA 随机对照试验的结果。

背景：患有 BRCA1/2 致病变异（PVs）的妇女可以选择不同的预防方案。为了帮助这些妇女自己做出决定，我们制定并实施了一项决策指导（DC）计划，并对参与者在决策中的期望角色与实际角色之间的一致性进行了评估。交回基线 T1 问卷的人被随机分配到干预组（IG）或对照组（CG）。干预组参加由护士主导的 DC 计划。主要结果是参与者在决策中的期望角色与实际角色之间的一致性。次要结果包括积极角色、满意度、决策冲突和知识。通过问卷调查获得了 12 周（T2）和 6 个月（T3）的随访数据：在招募的 413 名妇女中，有 389 人交回了 T1 基线问卷。在 T2 阶段，IG 组和 CG 组在决策中的期望角色和实际角色的一致性方面没有显著差异（0.12 [95% 置信区间 -0.03; 0.28]，p=0.128），CG 组的一致性略高。两组女性在 T2 阶段的活跃程度都高于她们在 T1 阶段所表达的意愿，其中 IG 阶段的比例明显更高（IG：40%；CG：24.4%；[-25.1; -6.1]）。IG 参与者对自己所承担的角色更加满意，决策冲突更少，知识更丰富：这些研究结果表明，DC 计划可以帮助患有 BRCA1/2 PVs 的妇女积极参与有关预防措施的决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.