Tumour budding as a risk factor for lymph node metastases in cutaneous squamous cell carcinoma: a systematic review and meta-analysis.

IF 3.7 4区医学 Q1 DERMATOLOGY

Clinical and Experimental Dermatology Pub Date : 2024-10-24 DOI:10.1093/ced/llae155

Pedro Gil-Pallares, Maria Eugenia Gil-Pallares, Alba Navarro-Bielsa, Olalla Figueroa-Silva, Laura Taboada-Paz, José Manuel Suárez-Peñaranda

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引用次数: 0

Abstract

Background: Current staging systems have limitations in stratifying high-risk cutaneous squamous cell carcinoma (cSCC). Tumour budding (TB) has emerged as a potential prognostic factor in various cancers.

Objectives: To evaluate the prognostic significance of TB in predicting lymph node metastases (NM) in cSCC.

Methods: A comprehensive search of the PubMed, Web of Science, Embase and Cochrane databases was conducted. Studies investigating the association of TB using a 5-bud cutoff and NM in cSCC were included. A meta-analysis was performed using odds ratios (OR) to evaluate the association between TB and NM.

Results: Six retrospective studies comprising 793 patients with cSCC were included. The random-effects analysis showed a significant association between high TB (≥ 5 buds) and NM (OR = 13.29, 95% confidence interval 5.55-31.86).

Discussion: TB is a promising histopathological feature for predicting NM in cSCC. The results show a strong association between high TB and NM, supporting its utility as a risk factor for NM in cSCC. Its inclusion in clinical practice and cSCC staging might be helpful in the stratification of patients with high-risk cases and to guide optimal management strategies for each patient. However, further investigation is needed to determine standardized reporting guidelines for TB in cSCC.

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肿瘤萌芽是皮肤鳞状细胞癌淋巴结转移的风险因素：系统综述和荟萃分析。

背景：目前的分期系统在对皮肤鳞状细胞癌（cSCC）高危病例进行分层方面存在局限性。肿瘤萌芽（TB）已成为各种癌症的潜在预后因素：本系统综述和荟萃分析旨在评估 TB 在预测 cSCC 淋巴结转移（NM）方面的预后意义：方法：对 PubMed、Web of Science、EMBASE 和 Cochrane 数据库进行了全面检索。方法：对PubM、Web Science、EMBASE和Cochrane数据库进行了全面检索，纳入了采用5芽截断法调查肺结核与cSCC NM相关性的研究。采用几率比（OR）进行荟萃分析，评估结核与NM之间的关系：结果：共纳入了六项回顾性研究，包括 793 名 cSCC 患者。随机效应分析显示，高TB（≥5个芽）与NM之间存在显著关联（OR = 13.29，95% CI = 5.55; 31.86）：讨论：肿瘤出芽是预测cSCC NM的一个有希望的组织病理学特征。研究结果表明，高TB与NM之间存在很强的相关性，支持其作为cSCC中NM风险因素的实用性。将其纳入临床实践和 cSCC 分期可能有助于对高风险病例进行分层，并为每位患者的最佳治疗策略提供指导。不过，要确定 cSCC 中结核病的标准化报告指南，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

2.40%

发文量

389

审稿时长

3-8 weeks

期刊介绍： Clinical and Experimental Dermatology (CED) is a unique provider of relevant and educational material for practising clinicians and dermatological researchers. We support continuing professional development (CPD) of dermatology specialists to advance the understanding, management and treatment of skin disease in order to improve patient outcomes.