Comparison of the Effectiveness of Ceftobiprole and Vancomycin in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus-Induced Meningitis.

IF 2 4区医学 Q3 ONCOLOGY

Chemotherapy Pub Date : 2024-01-01 Epub Date: 2024-05-02 DOI:10.1159/000527531

Sinan Mermer, Tuncer Turhan, Elif Bolat, Sohret Aydemir, Hilal Sipahi, Oguz Resat Sipahi

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引用次数: 0

Abstract

Introduction: Nosocomial meningitis may occur after procedures affecting the central nervous system or following traumatic injury. The causative infectious organism is commonly Staphylococcus aureus, a Gram-positive bacterium. The aim of the present study was to compare the effectiveness of two antibacterial agents, ceftobiprole and vancomycin, in an animal model of methicillin-resistant S. aureus (MRSA) meningitis.

Method: The strain of MRSA used was ATCC 43300. The animals were divided into three groups and infected intracisternally with MRSA. Controls received no antibiotherapy while the ceftobiprole group received 25 mg/kg and the vancomycin group received 20 mg/kg intravenously. Blood and cerebrospinal fluid (CSF) samples were collected at three time points. All animals were euthanized at 73 h after start of treatment.

Results: There was a significant difference (p < 0.05) between both treatment groups and the control animals at 24 h (drug trough) and 73 h (1 h after third dose) after start of treatment in terms of CSF bacterial levels. At 73 h, there was a significant difference in survival between the control group and the two treatment groups but no difference between the treated animal survival rates.

Conclusion: Intravenous treatment with ceftobiprole and vancomycin appears to be equally effective in a rabbit model of MRSA meningitis.

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在耐甲氧西林金黄色葡萄球菌诱发的兔脑膜炎模型中比较头孢替比妥和万古霉素的疗效。

介绍：影响中枢神经系统的手术后或外伤后可能会发生非细菌性脑膜炎。致病菌通常是金黄色葡萄球菌，一种革兰氏阳性细菌。本研究旨在比较两种抗菌药头孢替吡咯和万古霉素在耐甲氧西林金黄色葡萄球菌（MRSA）脑膜炎动物模型中的疗效：方法：使用的 MRSA 菌株为 ATCC 43300。方法：使用的 MRSA 菌株为 ATCC 43300，将动物分为三组，并用 MRSA 在其体内进行感染。对照组不接受抗生素治疗，头孢替比普乐组静脉注射 25 毫克/千克，万古霉素组静脉注射 20 毫克/千克。在三个时间点采集血液和脑脊液（CSF）样本。所有动物在治疗开始后 73 小时安乐死：结果：所有动物在治疗开始后 73 小时安乐死：总之，在 MRSA 脑膜炎兔模型中，头孢替比妥和万古霉素的静脉治疗似乎同样有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemotherapy 医学-药学

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal publishes original research articles and state-of-the-art reviews on all aspects of antimicrobial and antitumor chemotherapy. The results of experimental and clinical investigations into the microbiological and pharmacologic properties of antibacterial, antiviral and antitumor compounds are major topics of publication. Papers selected for the journal offer data concerning the efficacy, toxicology, and interactions of new drugs in single or combined applications. Studies designed to determine the pharmacokinetic and pharmacodynamics properties of similar preparations and comparing their efficacy are also included. Special emphasis is given to the development of drug-resistance, an increasing problem worldwide.