Analysis of the relationship between age-related erythrocyte dysfunction and fatigue.

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY
Biogerontology Pub Date : 2024-10-01 Epub Date: 2024-05-07 DOI:10.1007/s10522-024-10106-w
Yuichiro Ogata, Takaaki Yamada, Masahiro Fujimura, Toshio Igarashi, Seiji Hasegawa
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Abstract

With the declining birth rates and aging societies in developed countries, the average age of the working population is increasing. Older people tend to get tired more easily, so prevention of fatigue is important to improve the quality of life for older workers. This study aimed to assess the mechanism of fatigue in older people, especially focused on relation between dysfunction of erythrocyte and fatigue. Total power (TP), which is the value of autonomic nerve activity, was measured as a value of fatigue and significantly decreased in workers with aging. As properties of senescent erythrocytes, the erythrocyte sedimentation rate and damaged erythrocytes population increased with aging and correlated with TP. These results suggested that the accumulation of damaged erythrocytes contributes to fatigue. Recent studies revealed that senescence-associated secretory phenotype (SASP), a phenomenon in which senescent cells secrete a variety of cytokines, affected hematopoiesis in bone marrow. We analyzed the effects of SASP factors on erythropoiesis and found that Interleukin -1α (IL-1α) suppressed erythrocyte differentiation of hematopoietic stem cells in vitro. We also showed that IL-1α levels in human blood and saliva increase with aging, suggesting the possibility that IL-1α level in saliva can be used to predict the decline in hematopoietic function.

Abstract Image

分析与年龄有关的红细胞功能障碍和疲劳之间的关系。
随着发达国家出生率的下降和社会的老龄化,劳动人口的平均年龄在不断增加。老年人更容易疲劳,因此预防疲劳对提高老年劳动者的生活质量非常重要。本研究旨在评估老年人疲劳的机制,尤其关注红细胞功能障碍与疲劳之间的关系。总功率(TP)是自律神经活动的数值,被测量为疲劳的数值,随着年龄的增长,工人的总功率显著下降。作为衰老红细胞的特性,红细胞沉降率和受损红细胞数量随着年龄的增长而增加,并与总功率相关。这些结果表明,受损红细胞的积累会导致疲劳。最近的研究发现,衰老相关分泌表型(SASP)(一种衰老细胞分泌多种细胞因子的现象)会影响骨髓造血。我们分析了SASP因子对红细胞生成的影响,发现白细胞介素-1α(IL-1α)抑制了体外造血干细胞的红细胞分化。我们还发现,人体血液和唾液中的IL-1α水平会随着年龄的增长而增加,这表明唾液中的IL-1α水平可用于预测造血功能的衰退。
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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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