Gamma Knife Stereotactic Radiosurgery for Cerebral Cavernous Malformations: Meta-Analysis of Reconstructed Time-to-Event Data.

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY

Cerebrovascular Diseases Pub Date : 2024-04-30 DOI:10.1159/000539079

Gustavo da Fontoura Galvão, Gabriel Verly, Matheus Duque Bessa, Bernardo Lisboa Galvão Santos, Pablo Valença, Flávio Sampaio Domingues, Marcello Reis da Silva, Jorge Marcondes

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引用次数: 0

Abstract

Introduction: Cavernomas are vascular lesions with a genetic heritage that can be spotted on the central nervous system. Whenever these lesions are localized in eloquent regions, surgical resection is not recommended. In this type of situation, Gamma Knife stereotactic radiosurgery (GKSRS) could be a feasible option for treating patients. Thus, we aimed to explore the outcomes associated with this procedure.

Methods: We performed a systematic review and meta-analysis of reconstructed time-to-event data based on Kaplan-Meier curves. A thorough search was conducted on PubMed, Cochrane, Web of Science, and Embase databases targeting papers that provided information regarding hemorrhagic outcomes associated with GKSRS through Kaplan-Meier curves.

Results: After a systematic search in the specific databases, seven studies were included in this review. Notably, a total of 1,071 patients had 1,104 cavernomas treated by GKSRS. Assessment of short-term and long-term post-procedure outcomes was performed, with the estimated overall events-free rate at 2 years being 89.8% (95% CI: 87.7-91.5), while, at 10 years, the estimated overall events-free rate was 71.3% (95% CI: 67.2-75.1).

Conclusion: GKSRS seems to be a good alternative for the control of symptomatic events in early and long-term follow-up, despite the need for further investigation provided by future studies.

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伽玛刀放射外科治疗脑海绵状畸形：重构事件发生时间数据的 Meta 分析。

导言海绵状瘤是一种可在中枢神经系统中发现的遗传性血管病变。只要这些病变位于有神经功能的区域，就不建议进行手术切除。在这种情况下，伽玛刀立体定向放射外科手术（GKRS）可能是治疗患者的可行选择。因此，我们旨在探讨与该手术相关的结果：我们对基于 Kaplan-Meier 曲线的事件发生时间数据进行了系统回顾和荟萃分析。我们在 PubMed、Cochrane、Web of Science 和 Embase 数据库中进行了全面搜索，目标是通过 Kaplan-Meier 曲线提供与 GKRS 相关的出血结果信息的论文：结果：在对特定数据库进行系统检索后，本综述纳入了七项研究。值得注意的是，共有 1071 名患者的 1104 个海绵体瘤接受了 GKRS 治疗。对手术后的短期和长期疗效进行了评估，估计2年的总体无事件发生率为89.8%（95% CI 87.7 - 91.5），而10年的总体无事件发生率估计为71.3%（95% CI 67.2 - 75.1）：GKRS似乎是在早期和长期随访中控制症状性事件的一个很好的选择，尽管还需要未来的研究提供进一步的调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cerebrovascular Diseases 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.