Regulation of fadR on the ROS defense mechanism in Shewanalla oneidensis.

IF 2 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnology Letters Pub Date : 2024-08-01 Epub Date: 2024-05-06 DOI:10.1007/s10529-024-03487-y

Qiu Meng, Yinming Xu, Liming Dai, Xuzhe Ge, Pei Qiao

引用次数: 0

Abstract

Protein FadR is known as a fatty acid metabolism global regulator that sustains cell envelope integrity by changing the profile of fatty acid. Here, we present its unique participation in the defense against reactive oxygen species (ROS) in the bacterium. FadR contributes to defending extracellular ROS by maintaining the permeability of the cell membrane. It also facilitates the ROS detoxification process by increasing the expression of ROS neutralizers (KatB, KatG, and AhpCF). FadR also represses the leakage of ROS by alleviating the respiratory action conducted by terminal cytochrome cbb3-type heme-copper oxidases (ccoNOQP). These findings suggest that FadR plays a comprehensive role in modulating the bacterial oxidative stress response, instead of merely strengthening the cellular barrier against the environment. This study sheds light on the complex mechanisms of bacterial ROS defense and offers FadR as a novel target for ROS control research.

查看原文本刊更多论文

fadR 对 Shewanalla oneidensis 中 ROS 防御机制的调控。

众所周知，蛋白质 FadR 是脂肪酸代谢的全局调节因子，它通过改变脂肪酸的结构来维持细胞包膜的完整性。在这里，我们介绍了它在细菌防御活性氧（ROS）过程中的独特参与。FadR 通过维持细胞膜的通透性来抵御细胞外的 ROS。它还通过增加 ROS 中和剂（KatB、KatG 和 AhpCF）的表达来促进 ROS 解毒过程。FadR 还能减轻末端细胞色素 cbb3 型血红素铜氧化酶（ccoNOQP）的呼吸作用，从而抑制 ROS 的泄漏。这些研究结果表明，FadR 在调节细菌氧化应激反应中发挥着全面的作用，而不仅仅是加强细胞对环境的屏障。这项研究揭示了细菌防御 ROS 的复杂机制，并将 FadR 作为 ROS 控制研究的新目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biotechnology Letters 工程技术-生物工程与应用微生物

CiteScore

5.90

自引率

3.70%

发文量

108

审稿时长

1.2 months

期刊介绍： Biotechnology Letters is the world’s leading rapid-publication primary journal dedicated to biotechnology as a whole – that is to topics relating to actual or potential applications of biological reactions affected by microbial, plant or animal cells and biocatalysts derived from them. All relevant aspects of molecular biology, genetics and cell biochemistry, of process and reactor design, of pre- and post-treatment steps, and of manufacturing or service operations are therefore included. Contributions from industrial and academic laboratories are equally welcome. We also welcome contributions covering biotechnological aspects of regenerative medicine and biomaterials and also cancer biotechnology. Criteria for the acceptance of papers relate to our aim of publishing useful and informative results that will be of value to other workers in related fields. The emphasis is very much on novelty and immediacy in order to justify rapid publication of authors’ results. It should be noted, however, that we do not normally publish papers (but this is not absolute) that deal with unidentified consortia of microorganisms (e.g. as in activated sludge) as these results may not be easily reproducible in other laboratories. Papers describing the isolation and identification of microorganisms are not regarded as appropriate but such information can be appended as supporting information to a paper. Papers dealing with simple process development are usually considered to lack sufficient novelty or interest to warrant publication.