Enterococci as a One Health indicator of antimicrobial resistance.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-01 Epub Date: 2024-05-02 DOI:10.1139/cjm-2024-0024

Sani-E-Zehra Zaidi, Rahat Zaheer, Athanasios Zovoilis, Tim A McAllister

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Abstract

The rapid increase of antimicrobial-resistant bacteria in humans and livestock is concerning. Antimicrobials are essential for the treatment of disease in modern day medicine, and their misuse in humans and food animals has contributed to an increase in the prevalence of antimicrobial-resistant bacteria. Globally, antimicrobial resistance is recognized as a One Health problem affecting humans, animals, and environment. Enterococcal species are Gram-positive bacteria that are widely distributed in nature. Their occurrence, prevalence, and persistence across the One Health continuum make them an ideal candidate to study antimicrobial resistance from a One Health perspective. The objective of this review was to summarize the role of enterococci as an indicator of antimicrobial resistance across One Health sectors. We also briefly address the prevalence of enterococci in human, animal, and environmental settings. In addition, a 16S RNA gene-based phylogenetic tree was constructed to visualize the evolutionary relationship among enterococcal species and whether they segregate based on host environment. We also review the genomic basis of antimicrobial resistance in enterococcal species across the One Health continuum.

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肠球菌是抗菌药耐药性的一种健康指标。

人类和牲畜中耐药性细菌的迅速增加令人担忧。抗菌素是现代医学治疗疾病的基本药物，而人类和食用动物滥用抗菌素导致了抗菌素耐药性细菌的增加。在全球范围内，抗菌药耐药性被认为是影响人类、动物和环境的 "一体健康 "问题。肠球菌属革兰氏阳性细菌，在自然界中广泛分布。它们在整个 "一体健康 "过程中的发生率、流行率和持久性使其成为从 "一体健康 "角度研究抗菌药耐药性的理想候选菌。本综述旨在总结肠球菌作为 "一体健康 "领域抗菌药耐药性指标的作用。我们还简要介绍了肠球菌在人类、动物和环境中的流行情况。此外，我们还构建了一棵基于 16S RNA 基因的系统发生树，以直观显示肠球菌物种之间的进化关系，以及它们是否会根据宿主环境发生分离。我们还回顾了 "一个健康连续体 "中肠球菌耐药性的基因组基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.