Nico Nys*, Lorenz Buchgraber, Peter Neugebauer, Matthew J. Jones and Heidrun Gruber-Woelfler*,
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引用次数: 0
Abstract
Additive manufacturing (3D printing) has been shown to be a viable route to realize crystallizer design and affords the opportunity to accelerate development of novel, lab scale designs as well as the ability to rapidly adapt tailor-made equipment to the requirements of a specific application. This article presents a novel, modular crystallizer design, and the design rationale is discussed. The crystallizer consists of a heated, cylindrical mantle in conjunction with a concentric internal cylinder with a lamellar surface structure designed to keep particles in lateral motion relative to the direction of fluid flow. Using a single module, fluid and particle residence times and particle size evolution have been evaluated as a function of operating parameters. The performance of the equipment over an extended period of time has been investigated with a view to characterizing its propensity for fouling and blockage.
期刊介绍：
The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.
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